Protein Alignment nAChRalpha5 and ort

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 99/447 - (22%)
• Similarity: 180/447 - (40%)
• Gaps: 99/447 - (22%)

  Fly   294 IFLLIYLNLSAKVCLAGY-----HEKRLLHDLLDP----YNTLERPVLNESDPLQLSFGLTLMQI 349
            :|.:|.| :...:|:..|     .:...:.|:|..    |:.: ||...|..|..:.|.:|:|.:
  Fly     2 VFQIIIL-VICTICMKHYAKGEFQQSLAITDILPEDIKRYDKM-RPPKKEGQPTIVYFHVTVMGL 64

  Fly   350 IDVDEKNQLLVTNVWLKLEWNDMNLRW---NTSDY-----GGVKDLRIPPHRIWKPDVLMYNSAD 406
            ..:||.:...|.:|:....|.|..||.   .|.:|     ..:|::       |:||....|:..
  Fly    65 DSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNM-------WRPDSFFKNAKS 122

  Fly   407 EGFDGTYQTNVV------VRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL 465
            .    |:||..:      :..:.:.||:.....|.:|.::...:|.|.|.|:::..|.::....|
  Fly   123 V----TFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDL 183

  Fly   466 DLQLQDETGGDISSYVLNGEWELLGVPGKRNE------IY----YNCCPEPYIDITFAIIIRRRT 520
            ..|....|     ..|::...||..|...|||      :|    :.|     :::.|.  ::||.
  Fly   184 IFQWDPTT-----PLVVDENIELPQVALIRNETADCTQVYSTGNFTC-----LEVVFT--LKRRL 236

  Fly   521 LYYFFNLIIPCVLIASMALLGFTLPPDSG-EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLG 584
            :||.||..||..:|..|:.:.|.:.|::. .:::||||.||:|:........::|..|
  Fly   237 VYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVS------- 294

  Fly   585 TYFNCI-MFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFP- 647
             |...: .||...:|...:.::.|...|            :.|...|....|:.|.:|:..:.|
  Fly   295 -YLKAVDAFMSVCTVFVFMALMEYCLIN------------IVLSDTPIPKPMAYPPKPVAGDGPK 346

  Fly   648 -----TTPCSDTSSERKHQI----LSDVELKERSSKSLLANVLDIDDDFRHNCRPMT 695
                 ..|....|:..|.|.    |:|.::::         :..|.|:...|.|.:|
  Fly   347 KEGEGAPPGGSNSTASKQQATMLPLADEKIEK---------IEKIFDEMTKNRRIVT 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	94/423 (22%)
ort	NP_524406.1	LIC	31..481	CDD:455710	94/417 (23%)
		LGIC_ECD_HisCl	51..235	CDD:349793	44/206 (21%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)