Protein Alignment nAChRalpha5 and nAChRalpha2

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 211/561 - (37%)
• Similarity: 302/561 - (53%)
• Gaps: 74/561 - (13%)

  Fly   291 HSW-----IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQII 350
            |.|     :.||:.|.|..:...|....|||..|||..||.|.|||.|.:|.:.:..||.|.|:|
  Fly    18 HIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLI 82

  Fly   351 DVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQT 415
            |::.|:|:|.|||||:.||.|...:|:.|:||||.:|.:|...||.||:::||:||..:..|..|
  Fly    83 DLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMT 147

  Fly   416 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL----QLQD----- 471
            ..::...|..::.||.||||:|:||:.:||||.|.|.||||||||||.|:||    |..|
  Fly   148 KAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKV 212

  Fly   472 ETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIAS 536
            |.|.|:..|..:.||::||||.:|:|.||.||.|||.||.|.|.:||:||:|..|||||||.|:.
  Fly   213 EIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISY 277

  Fly   537 MALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVST 601
            :::|.|.||.|||||::|.::||||.|:|..:::|.:|:||.|:||||.|....|.:|..|||.|
  Fly   278 LSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVIT 342

  Fly   602 ILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDV 666
            |:|||.|:|...||:|..|||..|:..||.:|.|..|                     ..:|.|:
  Fly   343 IIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVP---------------------KDLLRDL 386

  Fly   667 ELKE-----RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGD----------- 715
            ...:     :.||:.....| :|:      ..|..||:.|.:....:...|.|.
  Fly   387 AANKINYGLKFSKTKFGQAL-MDE------MQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATN 444

  Fly   716 --DGSIGPIGS--------TRMPDAVT------HHTCIKSSTEYELGLILKEIRFITDQLRKDDE 764
              .|.:|.:|.        ..:|..::      .....:....:||...:..:.||...:::.||
  Fly   445 RFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDE 509

  Fly   765 CNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHI 805
            .|....||.|.|||:|||.|.:|.:.:::.|..:|..||.:
  Fly   510 FNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSL 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	202/529 (38%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	106/218 (49%)
		LIC	47..544	CDD:273305	200/524 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010