Protein Alignment nAChRalpha5 and nAChRalpha1

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 219/590 - (37%)
• Similarity: 319/590 - (54%)
• Gaps: 79/590 - (13%)

  Fly   292 SWIFLLIYLNLS-AKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            |.:|..:::.|. |...||....|||..|||..||.|.|||.|.||.|.:..||.|.|:|||:.|
  Fly     3 SVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            ||::.||||::.||||..|:||..|||||..|.:|...||.||:::||:||..::.|..|..::.
  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL----QLQD----ETGGDI 477
            :.|..::.||.|:||.|:||:.:||||:|.|.||||||||||:.:||    |..|    |.|.|:
  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197

  Fly   478 SSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGF 542
            ..|.::.||:::.||..|||.:|:||.|||:||.|.:.:||:||:|..|||||||.|:.:::|.|
  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262

  Fly   543 TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNY 607
            .||.|||||:||.::||||||||..::||.:|.||..|||||.|....|.:|..|||.||.:||.
  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327

  Fly   608 HHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDV-ELKER 671
            :.|:..||.|:.|::.:|:..||.:|.:.||.:           .:...::..::|:|| .|..
  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKK-----------EEPEEDQPPEVLTDVYHLPP- 380

  Fly   672 SSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYR-----------------------TVYGQ 713
                      |:|....::.:..:....:|..||.:|                       .:.|.
  Fly   381 ----------DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGA 435

  Fly   714 GDD-----GSIGPIGSTRMPDAVTHHTCIKSST-----EYELGLILKEIRFITDQLRKDDECNDI 768
            .||     |..|.|.....|.|........|.|     ..|:...::..|||...::..|:...:
  Fly   436 DDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESV 500

  Fly   769 ANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII-VSXPYGRGGYCYWFYYKINLLIIKLI 832
            ..|||:.|||:||:.|.||.:..::.|..::|.||.:. .|.|             |::|..|:.
  Fly   501 EEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQP-------------IDILYSKIA 552

  Fly   833 TKLFK 837
            .|.|:
  Fly   553 KKKFE 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	204/530 (38%)
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	106/217 (49%)
		LIC	27..530	CDD:455710	202/524 (39%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)