Protein Alignment nAChRalpha5 and nAChRalpha4

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 207/516 - (40%)
• Similarity: 303/516 - (58%)
• Gaps: 44/516 - (8%)

  Fly   314 KRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT 378
            |||..|||..||.|.|||:|.:|.|::...|.|.|:|||:.|||::.||:|::..|.|..|||..
  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77

  Fly   379 SDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITW 443
            .:||||..|.:|...||:||:::||:||..|:.|..|...:.:.|...:.||.|:||:|:||:.:
  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142

  Fly   444 FPFDDQRCEMKFGSWTYDGFQLDLQLQDE--------TGGDISSYVLNGEWELLGVPGKRNEIYY 500
            ||||:|.|.:||||||||||::||:..||        .|.|:|.:.::.||::|.||..|||.:|
  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207

  Fly   501 NCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVF 565
            .||.|||:||||.|.:||:||:|..|:||||:.|:.:.:|.|.||.|||||::|.::||:||.||
  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272

  Fly   566 LNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLP 630
            ..:|.|.:|.||..|||||.|....|.:|:.|:..|:::||.|.|:..||:|:.|::.||:.:||
  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLP 337

  Fly   631 WILRMSRP-----GRPLILEFPTTPC-----SDTSSERKHQILSDVEL-KERSSKSLLANVLDID 684
            ..|.:.||     ...|:|: .|..|     |.|:.:|......:..| ||..|:|:.||
  Fly   338 AFLFIKRPTYNFETSKLLLK-DTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITAN----- 396

  Fly   685 DDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMP----DAVTHHTCIKSSTEYEL 745
            ..|..:|:...|...|.|..:   .......|..|||:| .:.|    .|.:|..|:..
  Fly   397 GPFGGSCQVHGPVPPLTHCSS---DEIAAVPDMDIGPLG-MKSPILNNPAFSHSKCLPK------ 451

  Fly   746 GLILKE---IRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAP 803
              |.|.   :|||.:..:..::...:..|||:.|||:|||.|.|||:..::.|..::|.||
  Fly   452 --IHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	205/513 (40%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	204/509 (40%)
		Neur_chan_LBD	12..227	CDD:280998	102/213 (48%)
		Neur_chan_memb	234..505	CDD:280999	98/288 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940