DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and chrnd

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_996947.1	Gene:	chrnd / 404273	ZFINID:	ZDB-GENE-030131-6665	Length:	518	Species:	Danio rerio

Alignment Length:	516	Identity:	167/516 - (32%)
Similarity:	264/516 - (51%)	Gaps:	61/516 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 CLAGYHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEW 369
            |.....|:||::.|...  ||...|||.|:.:.:.:...|||..:|.:.|.::.|:||||::..|
Zfish    19 CCGRNEEERLINYLFKERGYNKELRPVQNKDETVDIYLALTLSNLISLKEVDETLLTNVWMEHGW 83

  Fly   370 NDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFK 434
            .|..|.||.|:| .:..||:||..:|.|::::.|:.|..|...|..||::.::|...::||.||:
Zfish    84 KDHRLTWNESEY-DIPVLRLPPSMVWLPEIVLENNNDAQFQVAYYCNVLIYSSGDMYWLPPAIFR 147

  Fly   435 STCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG-----------DISSYVLNGEWEL 488
            |:|.|::.:||||.|.|.:||.|.||:..::.|.|:.|...           |...:..|||||:
Zfish   148 SSCSINVNYFPFDWQNCSLKFSSLTYNAKEISLNLKMEQENTTYYKVEWIIIDPEGFTENGEWEI 212

  Fly   489 LGVPGKRNEIYYNCCPE---PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            :..|.:||  .|...|:   .:.||||.:||:|:.|:|..|:|||||||:.:|.|.:.||.||||
Zfish   213 VHKPARRN--IYKSIPKESNKHQDITFYLIIKRKPLFYIVNIIIPCVLISFLASLVYYLPADSGE 275

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |::|.:::||:.:|||.::::.:|.||.||||:..|...||.:|...|::.:::||.|.|...||
Zfish   276 KMTLSISVLLAQSVFLLLISQRLPETSMAVPLIVKYLMFIMVLVTVVVLNCVIVLNLHFRTPSTH 340

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKER--SSKSLLA 678
            .|:||.:..||..||.:|.||.|       ....|..:::..|:...|..:...|.  |.||...
Zfish   341 VMTEWTKEFFLERLPRLLHMSLP-------VEDQPVPESALPRRSSSLGYIAQAEEYYSVKSRSE 398

  Fly   679 NVLDIDDDFRHN--CRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSST 741
            .:.:...: ||.  .|| ||..|           |...:|..:.......|..||
Zfish   399 LMFEKQSE-RHGLAARP-TPKAT-----------YTSSNDSEVSEQLYNEMKPAV---------- 440

  Fly   742 EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSA 802
                    :...:|...:...::.|:..::|...|..|||||..:.|...::.||.:.|.|
Zfish   441 --------EGANYIVKHMHDKNDYNEEKDNWSGIARTVDRLCFYVVTPVMMIGTICIFLMA 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	165/508 (32%)
chrnd	NP_996947.1	LIC	6..493	CDD:273305	166/514 (32%)
		Neur_chan_LBD	25..245	CDD:280998	79/222 (36%)
		Neur_chan_memb	252..490	CDD:280999	82/275 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910