Protein Alignment nAChRalpha5 and Grd

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 100/501 - (19%)
• Similarity: 173/501 - (34%)
• Gaps: 158/501 - (31%)

  Fly   224 LVSLQQWQLHVQQRSVL-LFRRIAASTIAFIS-YLGSFAAQLRSSSSSSSNSSNS---------- 276
            |::.:....|..|||.| :|:.:.:..:..:. |..::...:...|...|.|::|
  Fly    20 LIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRL 84

  Fly   277 ---GNSSSTQI----LNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNE 334
               |.|.|:.:    |...|.|:        |:|           .||.:||..|:...||...
  Fly    85 GEMGTSLSSSLPSSWLTQSNNHA--------NIS-----------ELLDNLLRGYDNSIRPDFG- 129

  Fly   335 SDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKD---LRIPP-HRIW 395
            ..|..:...:.:..:..:.|.:.....:.:.:..|.|..|.     :.|.:|   |.:.. .|||
  Fly   130 GPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLA-----FEGAQDTLALSVSMLARIW 189

  Fly   396 KPDVLMYNSADEGFDGTYQTNVVVR--NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSW 458
            |||...||............|..||  .||..||......|:.|.:::..||.|.|:|.:||||:
  Fly   190 KPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSF 254

  Fly   459 TY--------------------------------------------------------------- 460
            .|
  Fly   255 GYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPT 319

  Fly   461 -------------------DGFQLDLQL----QDETGGDISSYVLNGEWELLGVPGKRNEIYYNC 502
                               .|.:||...    :|.|||..|:..|:|...|     :.|.
  Fly   320 SKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITL-----ETNH----- 374

  Fly   503 CPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPD-SGEKLSLGVTILLSLTVFL 566
             |..|..:.....::|....:...:..||.|:..::.:.|.|..: :.:::|||:|.:|::| ||
  Fly   375 -PSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMT-FL 437

  Fly   567 NMVAET-MPATSDAVPLLGTYFNCIMFMVASSVVSTIL---ILNYH 608
            .:.|.| :|..|     ..|..:..:|:....:.:|||   :::|:
  Fly   438 GLEARTDLPKVS-----YPTALDFFVFLSFGFIFATILQFAVVHYY 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	80/393 (20%)
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	43/232 (19%)
		LIC	111..670	CDD:273305	80/391 (20%)
		Neur_chan_memb	398..667	CDD:280999	23/87 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030