Protein Alignment nAChRalpha5 and SecCl

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 118/553 - (21%)
• Similarity: 211/553 - (38%)
• Gaps: 113/553 - (20%)

  Fly   288 LNKHSWIFLLIYLNLSAKVCLAGYHE-----------------KRLLHDLLDPYNTLERPVLNES 335
            |::..||.|::.|::...|.:....|                 :||.|  :..|:.||||...:|
  Fly     6 LSEIFWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTH--VCRYDRLERPFEYDS 68

  Fly   336 DPLQLSFGL-TLMQIIDVDEKNQLLV---TNVWLKLEWNDMNLRW---NTSD-YGGVKDLRIPPH 392
            |..:|...: |.:.:..:...|..|:   .:..|:|.:.|..|.:   |.|| ..|.|.|   ..
  Fly    69 DGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL---SE 130

  Fly   393 RIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPG-IFKST-------CKIDITWFPFDDQ 449
            |:|.|.:...|..:....||.:.:|:...:      |.| :..||       |.::...||||.|
  Fly   131 RLWLPHIFFANERESSILGTDEKDVLTSLS------PEGNVIISTRMQASLYCWMNFQKFPFDQQ 189

  Fly   450 RCEMKFGSWTYDGFQLDLQLQDETGGD------ISSYVLNGEW-ELLGVPGKRNEIYYNCCPEPY 507
            .|.....||.|:...|.|:.:..|...      ::.|.:...| ....|....:.:.:......|
  Fly   190 FCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNY 254

  Fly   508 IDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPD-SGEKLSLGVTILLSLTVFLNMVAE 571
            ..::|.:.::|...:|..:..:|.::|.:::.:.|.|..| |..::.||.:.:||.....:..::
  Fly   255 SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSK 319

  Fly   572 TMPATS----DAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWI 632
            .:|..|    ..|..||..|.....:|..:.|:||                 |.|       ...
  Fly   320 NLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTI-----------------WRR-------KEN 360

  Fly   633 LRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERS-SKSLLANVLDIDDDFRHNCRPMTP 696
            :.:.:.....|::...||     ...:.||...:..:.|: |.|.|.|::...:..|:.
  Fly   361 IELKKVNSKYIIKSTLTP-----RPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNG------ 414

  Fly   697 GGTLPHNPAF--YRTVYGQGDDGSIGPIGSTRMPDAVTHHTC-IKSSTEYELGLILKEIRFITDQ 758
            .||:  |..|  |.||:..      .||..|...:|.|...| .:::.::.:.:         |:
  Fly   415 NGTV--NQGFNNYLTVHPN------LPIIRTECAEADTVSICSARTNNDHIVDV---------DK 462

  Fly   759 LRKDDECNDIANDWKFAAMVVDRLCLIIF-TMF 790
            .:||..........:..||.:||....:| .||
  Fly   463 DKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMF 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	112/528 (21%)
SecCl	NP_648984.2	LIC	43..505	CDD:455710	111/516 (22%)