Protein Alignment nAChRalpha5 and pHCl-1

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 167/842 - (19%)
• Similarity: 287/842 - (34%)
• Gaps: 279/842 - (33%)

  Fly    18 LAVRLAHCSSNISSSSSTRTTSSNKRHNQQLTTLQPR-----SLSTKHHSNIASEQHNSQQQEPA 77
            :|||    .:|...:...:...:.:::::..|..|..     :::|...:...:|.....|:|||
  Fly    40 VAVR----GNNDKPAEDIKIKDNYQQNHKTQTETQTEVAAVVAIATDAGAETETETEAEAQKEPA 100

  Fly    78 SKDEDV---------------ANHGRSNDQQTHLQQLDSSNMLSPKTAAAATAAGDEATTQQPTN 127
            :..|.:               .|:..|:.|.....:.:..:.|:.:.:...||||........|.
  Fly   101 TGPEHLKAAAQVLLTIRQARQENNKHSSSQVAETHKDEGEDALARQGSIVDTAAGRIGIDIAATT 165

  Fly   128 IRLCARK------RQRLRRRRKRKPATPNETDIKKQQQLSMPPFKTRKSTDTYSTPAAITSCPTA 186
            |::..|.      :|...|||:|:|                         |..:.||:||....
  Fly   166 IQVAERHEDGQHWQQHNVRRRRRQP-------------------------DPAAHPASITKLSA- 204

  Fly   187 TYMQCRASDNEFSIPISRHDRVSTATFAWVLHVLQVLLVSLQQWQ--LHVQQRSVLLFR------ 243
                           ||.|           .|.|..|..:||:.:  ..||.|..|.:|
  Fly   205 ---------------ISLH-----------FHALAALAKTLQKHEDLSPVQDRQPLAYRAWQEHP 243

  Fly   244 --------------------RIAASTIAFISYLGSFAAQLRSSSSSSSNSS---------NSGNS 279
                                ..||::.|...|||........|.|..:.||         .:..:
  Fly   244 YAETQMPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTA 308

  Fly   280 SSTQILNG-LNKH-----SW------------IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNT 326
            ::||...| |:||     .|            :.||:             .:||....||.|.|.
  Fly   309 AATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLL-------------EKKRYDKRLLPPVND 360

  Fly   327 ------LERPVL----NESDP-----LQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRW 376
                  |:.|.:    |...|     |.::..:.|:.:...||.:........|..:|||..|::
  Fly   361 EDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQY 425

  Fly   377 -NTSDYGGVKDLRIPPHR--IWKPDV--LMYNSADEGFDGTYQTNVV-------VRNNGSCLYVP 429
             |.|.|..:..|.   |.  ||.||.  :|:        |.::..::       :..||:..|..
  Fly   426 GNKSHYDFLNALH---HHDSIWTPDTYFIMH--------GDFKDPIIPMHFALRIFRNGTITYAM 479

  Fly   430 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL--------DLQLQDETGGDISSYVLNGEW 486
            ......:|:..:..|||||.:|.....|.:|:..|:        |...:..:...:::|::..:.
  Fly   480 RRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQT 544

  Fly   487 ELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS-GE 550
            ........|..  |:|.   .:::||.    |...|||..:.||.:::.:.:.:.|.|..:: ..
  Fly   545 TACDQNSWRGN--YSCL---QVELTFT----RDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPA 600

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN-----CIMFMVASSVVSTILILNYHHR 610
            ::.:|||.:|:.....|....|:|..|:.     |..|     |:.|:.||  :...:.:||..|
  Fly   601 RVMIGVTTMLNFFTTSNGFRSTLPVVSNL-----TAMNVWDGVCMCFIYAS--LLEFVCVNYVGR 658

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKS 675
            ....|      .:|:           |||     |.|.|       :|...:||.:.:
  Fly   659 KRPLH------NVVY-----------RPG-----ENPVT-------QRLPAVLSRIGV------- 687

  Fly   676 LLANVLDIDDDFRHNCRPMTP-----GGTLPHN---PAFYRTVYGQGDDGSIGPIGSTRMPD 729
            :||:.|        .....||     ||..|.:   ||         ...|:...|:.|:.|
  Fly   688 ILASPL--------ASAAATPAMSMMGGATPMSSGTPA---------ASSSVATPGTPRITD 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	100/466 (21%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	51/256 (20%)
		Neur_chan_memb	578..>682	CDD:280999	30/139 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100