Protein Alignment nAChRalpha5 and chrna7a

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_957513.1
• Gene: chrna7a / 394199
• ZFINID: ZDB-GENE-040108-3
• Length: 509
• Species: Danio rerio
• Alignment Length: 520
• Identity: 245/520 - (47%)
• Similarity: 337/520 - (64%)
• Gaps: 29/520 - (5%)

  Fly   293 WIFLLIYLNLSA--KVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            |.:.|.:.....  .|.|.|.|::||..||:..||.|||||.|::..|.:.|.::||||:|||||
Zfish     4 WEYTLYFTTTCCLWSVSLQGEHQRRLYRDLMKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEK 68

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            ||:|.||:||:|.|.|..|:||.|:|.||.::|.|..:|||||:|:||||||.||.|:.|||:|.
Zfish    69 NQVLTTNIWLQLYWYDYYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVN 133

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGE 485
            ::|:|.|:|||||||||.||:.|||||.|||::|||||||.|:.||||:.|   .||:.|:.|||
Zfish   134 SSGACQYLPPGIFKSTCYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQMID---ADITGYIANGE 195

  Fly   486 WELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            |:|:.|||:|||.:|:||.|||.|:||.:::|||||||..||:||||||:::|||.|.||.||||
Zfish   196 WDLVEVPGRRNERFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGE 260

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |:|||:|:|||||||:.:|||.||||||:|||:..||...|.:|..||::|:.:|.||:.:.:..
Zfish   261 KISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEGG 325

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
            :|.:|.|:|.|.|..|.|||.|||     |....|.......|......|:.:....::|...|:
Zfish   326 KMPKWTRVVLLNWCAWFLRMKRPG-----EDKVRPACHNKQPRSSLSSVDLNISPGVAQSTNGNL 385

  Fly   681 LDID----DDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSST 741
            |.|.    |...:        .|.|.:......:...|::..:       :|.|...........
Zfish   386 LYIGFRGMDTIHY--------ATSPDSGVICSRLVATGEEDVL-------LPGAQASSVSSSGPG 435

  Fly   742 EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII 806
            |.||..||.|:|:|:.:.|..||.:.:.|:|||||.|:|||||:.|::||||.||.:|:|||:.:
Zfish   436 ETELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNFV 500

  Fly   807  806
            Zfish   501  500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	236/492 (48%)
chrna7a	NP_957513.1	LIC	3..496	CDD:455710	242/514 (47%)