Protein Alignment nAChRalpha5 and Rdl

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 446
• Identity: 92/446 - (20%)
• Similarity: 162/446 - (36%)
• Gaps: 103/446 - (23%)

  Fly   300 LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVW 364
            :|:||           :|......|:...||... ..|:::...:.::.|..:.|.......:.:
  Fly    57 VNISA-----------ILDSFSVSYDKRVRPNYG-GPPVEVGVTMYVLSISSLSEVKMDFTLDFY 109

  Fly   365 LKLEWNDMNLRWNTSDYGGVKDLRIPPH---RIWKPDVLMYNSADEGFDGTYQTNVVVR--NNGS 424
            .:..|.|..|.:....  ||:.|.:...   .||.||....|.....|.....:|..:|  ::||
  Fly   110 FRQFWTDPRLAYRKRP--GVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGS 172

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWEL- 488
            ..........::|.:::.:||.|.|.|.::..|:.|.  ..|::.....|  :||..::.|.||
  Fly   173 ITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYT--MRDIRYFWRDG--LSSVGMSSEVELP 233

  Fly   489 ----LGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPD-S 548
                ||...:..||  |.....|..:...|...|...||...:.||..||..::.:.|.|..: :
  Fly   234 QFRVLGHRQRATEI--NLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNAT 296

  Fly   549 GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPL---LGTYFNCIMFMVASSVVSTILILNYHHR 610
            ..:::||||.:|::|..::.....:|..|....:   |||   |.:.:.||       :|.|
  Fly   297 PARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGT---CFVMVFAS-------LLEY--- 348

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKS 675
             |....|::.|::                                  ||.:.::..::.|:..:.
  Fly   349 -ATVGYMAKRIQM----------------------------------RKQRFMAIQKIAEQKKQQ 378

  Fly   676 LLANVLDIDDDFRHNCRPMT----PGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRM 727
                 ||..:..:.|..|..    |||.            |.|..|..||.|...:
  Fly   379 -----LDGANQQQANPNPNANVGGPGGV------------GVGPGGPGGPGGGVNV 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	89/433 (21%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	40/190 (21%)
		Cys-loop	185..199	CDD:349809	5/13 (38%)
		Neur_chan_memb	274..588	CDD:460753	41/209 (20%)