DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and nAChRbeta1

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	198/523 - (37%)
Similarity:	300/523 - (57%)	Gaps:	33/523 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 SWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            ||:...|.:.::..:..|...|:||:.||...||.|.|||.|.:..:.:.|||..:|:|:|:|||
  Fly     7 SWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            |::.:||||:|.|.|..|:|:.:||||:..||:||.::||||::::|:||..::..|::||::..
  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL-QDETGGDISSYVLNGE 485
            .|..|:|||.|::|:|.||:|:||||.|.|.|||||||::|.|:.|.| .::...|:|.|..:|.
  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201

  Fly   486 WELLGVPGKRNEIYYNCCPEP-YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
            |:::.||...| :|......| ..||||.|||||:||:|..|||:|.|||:.:.:|.|.||.::|
  Fly   202 WDIIEVPAYLN-VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||::||::|||||.|||.:|::.:|.||..:||:..|......|...|::.|::|:|::.|...|
  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330

  Fly   615 HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSS----KS 675
            |.|..:||.:||.:||..|.|.||.:..:......|.....:.......|..||.:..|    |.
  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395

  Fly   676 LLANVLDIDDDFRHNC---RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCI 737
            ....|:::.|....||   |.:..||.|           |.||    |....:...|::......
  Fly   396 SKMEVMELSDLHHPNCKINRKVNSGGEL-----------GLGD----GCRRESESSDSILLSPEA 445

  Fly   738 KSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSA 802
            ..:||        .:.||.:.||.:|.......|||:.|||:|||.|.||.:.|...|:.:|:.|
  Fly   446 SKATE--------AVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502

  Fly   803 PHI 805
            |||
  Fly   503 PHI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	190/497 (38%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	192/515 (37%)
		Neur_chan_LBD	28..236	CDD:280998	96/208 (46%)
		Neur_chan_memb	243..498	CDD:280999	89/277 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940