DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and acr-25

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001023570.2	Gene:	acr-25 / 3565563	WormBaseID:	WBGene00043066	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	218/563 - (38%)
Similarity:	310/563 - (55%)	Gaps:	71/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 KHSWIFLLIYLNLSAKVCLA------GYHEKR---LLHDLLDPYNTLERPVLNESDPLQLSFGLT 345
            ::.|:.|        |:||.      |..:|.   |..:||:.|..||||:.|.|:.:.:..||.
Worm     2 EYCWLIL--------KLCLLLALGRNGITQKSEGDLYTELLEDYEPLERPIENSSEAVMVKMGLV 58

  Fly   346 LMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFD 410
            |.||:|||||||::..|.|||..|.|.:|:|...|||||.|||....::|.||||||||||..||
Worm    59 LQQIVDVDEKNQVVDVNAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFD 123

  Fly   411 GTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG 475
            ..|.:|::|..||...::|||:::.:|||.:.|||||.|.|.:||||||:||.:|:|:: |:.|.
Worm   124 SRYASNLLVYPNGLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLEI-DDNGF 187

  Fly   476 DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            |||:|:.||||.|.|...|||..||.||||||.|:.|..:||||.|||.||||:||:||..:.|:
Worm   188 DISNYMQNGEWTLEGTTVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTLV 252

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            |||.|||:|||:||.:||:||:.:|.|.|||..|.||:|||.|..:|...:|..|..|.:|.|.|
Worm   253 GFTFPPDAGEKMSLQITIMLSICIFQNYVAELSPPTSEAVPFLSAFFAVCLFTCACCVTATTLAL 317

  Fly   606 NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            |:|||...:|:|:...|::.|.|:||:|.|.|||.       ...|.....:..    |:.|.:|
Worm   318 NFHHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPGY-------VARCGKIVKQDD----SEDEFEE 371

  Fly   671 RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQG--------------DDGSIGP 721
            |.::.....:..|...........||  |.|........|...|              :|..:..
Worm   372 RQTRLDQQRIATIISQITVESNKPTP--TFPRRVTIVDEVNSDGEAEEPLPPDEVIREEDDDVAS 434

  Fly   722 IG---------STRMPDAVTHHTCIKSSTEYELG-----------LILKEIR----FITDQLRKD 762
            :.         :|..|.....|....::.  .:|           |:|:::.    .|...:|:.
Worm   435 MDDPPAWRSTTTTSQPPQSPAHLWWNATN--RMGNRVPVEQIAQLLVLQQVHGHLSEINKHIRER 497

  Fly   763 DECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHI 805
            ::...|.:||||:|:||||:|::|||.|...:|:|:..|.|:|
Worm   498 EKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFASVPNI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	209/529 (40%)
acr-25	NP_001023570.2	Neur_chan_LBD	26..231	CDD:280998	106/205 (52%)
acr-25	NP_001023570.2	Neur_chan_memb	239..534	CDD:280999	95/309 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830