DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and lgc-28

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001022053.1	Gene:	lgc-28 / 3565225	WormBaseID:	WBGene00044301	Length:	397	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	73/400 - (18%)
Similarity:	143/400 - (35%)	Gaps:	105/400 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |.:|..|:...::  :...:.:...|||...|.:..|.|:.::..:|...:.....|.|..|.||
Worm    33 ETKLREDITKRFD--DTMPIKKDGYLQLIPLLHVDHIHDIQDEQGVLKMALTFTFTWMDERLMWN 95

  Fly   378 TSDYGGVKDLRIPPHRIWK-----PDVLMYNSADE----------GFDGTYQTNVVVRNNGSCLY 427
            .|:|.|::......|.:|:     |.::|.:..:.          ..|....::.:||.:...:.
Worm    96 PSNYSGIRTFSTTRHEMWRKKFWTPTLMMTDVPNSRRPSDVFKPFDMDIYISSSGMVRTSARMML 160

  Fly   428 VPPGIFKSTCKIDITWFPFDDQRC-----------EMKFGSWTYDGFQLDLQLQDETGGDISSYV 481
            ..|      |:.....:|.|.:.|           :.:|..|              .|.:.:.|:
Worm   161 TIP------CRTGFGSYPNDYKNCTFTLMSPYYADQFRFAQW--------------GGAEFTRYL 205

  Fly   482 LNG------EWELLGVPGKRNEIYYNCCPEPYID-------------ITFAIIIRRRTLYYFFNL 527
            ::.      :::|:.: ..||  ||.......:|             ..:.::::|...:....|
Worm   206 MSSRVTDVLDFQLINI-DTRN--YYMFLGSEVVDDFSKFKPRHCRSFYRYNLVLKRVNKFVSVQL 267

  Fly   528 IIPCVLIA-SMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIM 591
            |.|..:|| .:|:.|| ||...|  |....:.|:..|:|...|.:.:|.....:|::.... |.:
Worm   268 IAPISVIAVFLAISGF-LPHFYG--LVCAGSALVYETIFTYDVEQVLPKDYSGMPMIAILL-CFL 328

  Fly   592 FMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSS 656
            |                   |:|        ||.|.|.  :..::.....:...||.. ..|..:
Worm   329 F-------------------AET--------IVLLAWK--VFSINTRSHTVFTAFPEY-FDDEIT 363

  Fly   657 ERKHQILSDV 666
            .:|.::|..|
Worm   364 SKKEKLLKFV 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	72/399 (18%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	24/130 (18%)
		LIC	67..>329	CDD:273305	53/288 (18%)
		Cys-loop	164..178	CDD:349787	3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010