Protein Alignment nAChRalpha5 and ZACN

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_851321.2
• Gene: ZACN / 353174
• HGNCID: 29504
• Length: 412
• Species: Homo sapiens
• Alignment Length: 389
• Identity: 81/389 - (20%)
• Similarity: 148/389 - (38%)
• Gaps: 98/389 - (25%)

  Fly   297 LIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVT 361
            |..:|||.||                 ..:::.| .|.|.||.:...:.:..:.:||.....:.:
Human    37 LFNVNLSKKV-----------------QESIQIP-NNGSAPLLVDVRVFVSNVFNVDILRYTMSS 83

  Fly   362 NVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKP-----DVLMYNSADEG------FDGTYQT 415
            .:.|:|.|.|..|.||||.:.. ..:.:|...:|.|     :.|..:..|:.      .||..:.
Human    84 MLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKL 147

  Fly   416 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSY 480
            |:.:..            ::.|..::..||.|...|.:.|.:.:....:|:.|          ::
Human   148 NLALAT------------ETNCNFELLHFPRDHSNCSLSFYALSNTAMELEFQ----------AH 190

  Fly   481 VLNGEWELLGVPGKRNEIYYNC---CPEPYIDITFAIIIRRR--TLYYFFNLIIPCVLIASMALL 540
            |:|   |::.|  ||..:.|:.   .|...:...|.:.:|.:  .|.....|::|...:....:.
Human   191 VVN---EIVSV--KREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVC 250

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            |..||..:.|::...||:|||..|..:.:.:.:|::|...|||..||..::.::..|.:.|:|:.
Human   251 GGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLA 315

  Fly   606 NY---------------------HHRNADTHEMSE-----------W----IRIVFLCWLPWIL 633
            ..                     .|.|...|...|           |    .||.||.::..:|
Human   316 GLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQRSWPETADRIFFLVYVVGVL 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	75/373 (20%)
ZACN	NP_851321.2	LIC	11..368	CDD:273305	76/376 (20%)
		Neur_chan_LBD	54..>187	CDD:280998	30/145 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..360		4/31 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910