DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha5 and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	351/550 - (63%)
Similarity:	399/550 - (72%)	Gaps:	71/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 SWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            |...|||:|.:..:.| .|.||||||:.||..||||||||.|||:||::.|||||.|||||||||
  Fly    10 SLFVLLIFLAIIKESC-QGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKN 73

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            |:|.||.||.|||||.|||||.::|||||||||.|:::|||||||||||||||||||.||:||::
  Fly    74 QILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKH 138

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW 486
            ||||||||||||||||||||||||||||.||||||||||||.||||.|..|.|||:|.::.||||
  Fly   139 NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEW 203

  Fly   487 ELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEK 551
            .||.:|||:|.|.|.||||||:||||.|.|||||||||||||:|||||:||||||||||||||||
  Fly   204 YLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEK 268

  Fly   552 LSLGVTILLSLTVFLNMVAETMPATSDAV-----------------------------PLLGTYF 587
            |:||||||||||||||:|||:||.|||||                             |||||||
  Fly   269 LTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYF 333

  Fly   588 NCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCS 652
            ||||||||||||.|:::||||||.||.|||..||:.|||.||||||||.||||.:
  Fly   334 NCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKI---------- 388

  Fly   653 DTSSERKHQILS----DVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQ 713
                .||..:||    ::|||||||||||||||||||||||..                     .
  Fly   389 ----TRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTI---------------------S 428

  Fly   714 GDDGSIGPIGSTRMPDAV-THHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAM 777
            |...:||...|...|..| .|||.| .....:|.|||||::|||.::||.|:..::..|||||||
  Fly   429 GSQTAIGSSASFGRPTTVEEHHTAI-GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAM 492

  Fly   778 VVDRLCLIIFTMFTILATIAVLLSAPHIIV 807
            ||||.|||:||:|||:||:.||||||||||
  Fly   493 VVDRFCLIVFTLFTIIATVTVLLSAPHIIV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	336/522 (64%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	343/542 (63%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	139/180 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444976
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20350at7147
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
	13	12.780