DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and HTR3A

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_998786.3	Gene:	HTR3A / 3359	HGNCID:	5297	Length:	510	Species:	Homo sapiens

Alignment Length:	531	Identity:	144/531 - (27%)
Similarity:	222/531 - (41%)	Gaps:	109/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||...||..|....|||.:...|..:|..:.:..|::||||||:|.|.:|.:..|.|..|:||..
Human    36 RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 100

  Fly   380 DYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWF 444
            |:..:..|.||...||.||:|:....|.|..... ..|.:|:.|......|....:.|.:||..|
Human   101 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNF 164

  Fly   445 PFDDQRCEMKFGSW--TYDGFQLDL-QLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEP 506
            |||.|.|.:.|.||  |.....:.| :|.::...|.|.::..||||||||.....|.... ....
Human   165 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNY 228

  Fly   507 YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAE 571
            |.::.|.::||||.|:|..:|::|.:.:..|.::||.|||:|||::|..:|:||..:|||.:|::
Human   229 YAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 293

  Fly   572 TMPATSDAVPLL--------------------------------GTYFNCIMFMVASSVVSTILI 604
            |:|||:...||:                                |.||...|.::..|:..||.|
Human   294 TLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFI 358

  Fly   605 LNYHHRNADTHEMSEWIRIVFLCWLPWIL---RMSRPGRPLILEFPTT-------PCSDTSSERK 659
            :...|:......:..|:|.:.|..:.|:|   ..|...||     |.|       .||...:...
Human   359 VRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP-----PATSQATKTDDCSAMGNHCS 418

  Fly   660 HQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGS 724
            |                :....|.:...|..|.|..|    |.             :.|:...|
Human   419 H----------------MGGPQDFEKSPRDRCSPPPP----PR-------------EASLAVCG- 449

  Fly   725 TRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTM 789
                                   :|:|:..|...|.|.||..::|.||.....|:|:|...|:.:
Human   450 -----------------------LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 491

  Fly   790 FTILATIAVLL 800
            ..:..:|.:::
Human   492 AVLAYSITLVM 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	144/531 (27%)
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	144/531 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910