Protein Alignment nAChRalpha5 and nAChRalpha7

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 421/531 - (79%)
• Similarity: 464/531 - (87%)
• Gaps: 21/531 - (3%)

  Fly   296 LLIY---LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQ 357
            :|:|   |.:....|.||.|||||||.|||.||:|||||:|||||||||||||||||||||||||
  Fly    41 MLVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQ 105

  Fly   358 LLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNN 422
            ||:||:||||||||||||||:|::|||:||||||||:|||||||||||||||||||.||||||||
  Fly   106 LLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNN 170

  Fly   423 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWE 487
            ||||||||||||||||||||||||||||||||||||||||||||||||||.||||||::.||||:
  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWD 235

  Fly   488 LLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKL 552
            |||||||||||||||||||||||||||:|||:|||||||||:|||||||||||||||||||||||
  Fly   236 LLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKL 300

  Fly   553 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEM 617
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
  Fly   301 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEM 365

  Fly   618 SEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSS---ERKHQILSDVELKERSSKSLLAN 679
            |||||::||.|||.||||.|||: :..|.|..|.|.:||   |:|.|| .:||||||||||||||
  Fly   366 SEWIRVIFLYWLPCILRMQRPGQ-VGYECPPPPSSSSSSASGEKKQQI-QNVELKERSSKSLLAN 428

  Fly   680 VLDIDDDFR--HNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGST------RMPDAVTHHTC 736
            |||||||||  |.|    ...||||.|.:|||:|.||||||:||:|..      |:.:|:: |||
  Fly   429 VLDIDDDFRCNHRC----ASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAIS-HTC 488

  Fly   737 IKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLS 801
            :.||.||||.|||||:|:||:||:|:||.:||..||||||||||||||||||:|||:||:|||.|
  Fly   489 LTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFS 553

  Fly   802 APHIIVSXPYG 812
            |||.|||...|
  Fly   554 APHFIVSGVRG 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	406/499 (81%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	403/495 (81%)