Protein Alignment nAChRalpha5 and nAChRalpha3

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Alignment Length: 766
• Identity: 225/766 - (29%)
• Similarity: 315/766 - (41%)
• Gaps: 267/766 - (34%)

  Fly   294 IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQL 358
            |.:|.:::.|.    |....|||..|||..||.|.|||:|.:|.|.:...|.|.|:|||:.|||:
  Fly    11 ILVLSFISSST----ANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQI 71

  Fly   359 LVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNG 423
            :.||:|::..|.|..|:|...:||||:.|.:|...||:||:::||:||..|:.|..|...:...|
  Fly    72 MTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTG 136

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--------DISSY 480
            ...:.||.|:||:|:||:.:||||:|.|.||||||||||||:||:..||..|        |:|.:
  Fly   137 RVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEF 201

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            ..:.||::|.||..|||.:|.||.|||:||||.|.:||:||:|..||||||:.|:.:.:|.|.||
  Fly   202 YTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP 266

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
            .|||||:||.::||||||||..::||.:|.||..|||||.:....|.:...|:..|:|:||.|.|
  Fly   267 SDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFR 331

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLI----------------LEF------------- 646
            :..||.|:.|:|.||:..||..|.|.||..|:.                ||.
  Fly   332 SPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVAL 396

  Fly   647 ------PTTPCSDTSSERKHQI-------------------------------LSDVELKERSSK 674
                  |.|....||...:|::                               :|....:..::.
  Fly   397 SRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTS 461

  Fly   675 SLLANVLDIDDDFRHNCRPMTPGGTLPH--NPAFYRTV---------------YGQGDDGSIGPI 722
            ||      ||..: ||....|.|..|.|  .|..:|.:               .|.|..|..|..
  Fly   462 SL------IDAQY-HNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQS 519

  Fly   723 G---------------------------STRMPD-AVTHHTCIKSSTEY---------------- 743
            |                           ||...| .:.:...|||:|..
  Fly   520 GGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSG 584

  Fly   744 ----------------------------------------------------------------- 743
                                                                             
  Fly   585 TIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPS 649

  Fly   744 --------------------------------------------------------ELGLILKEI 752
                                                                    ||...:..:
  Fly   650 TSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGV 714

  Fly   753 RFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAP 803
            .:|.||.||::|...:..|||:.|||:|||.|.|||:..::.|..::|.||
  Fly   715 TYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAP 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	219/744 (29%)
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	103/214 (48%)
		Neur_chan_memb	248..>359	CDD:280999	54/110 (49%)
		Neur_chan_memb	<683..760	CDD:280999	22/76 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940