Protein Alignment nAChRalpha5 and chrnb3b

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 526
• Identity: 185/526 - (35%)
• Similarity: 278/526 - (52%)
• Gaps: 88/526 - (16%)

  Fly   294 IFLLIYLNLSAK--VCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            :|..|:....|:  |.|| ..|..||.||...|....||:|:.:..:::.|||.:.|::||||||
Zfish    11 LFTSIFATTPAREFVSLA-EREDALLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVDEKN 74

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            ||:.|||||..||.|..||||..:|||:..:|:|...||.||:::|.:||..|:|:..|..:||.
Zfish    75 QLMTTNVWLYEEWLDYKLRWNPENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAIVRY 139

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW 486
            ||...:.||..:||.|.:|:|:||||.|.|.||||||||||..::|.|.:.. .|.|.:..||||
Zfish   140 NGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ-VDRSDFFDNGEW 203

  Fly   487 ELL---GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS 548
            |:|   |..|.|.:.:|:   .||  ||::.|::|..|:|...|||||:.::.:.:|.|.||.|.
Zfish   204 EILSATGHKGSRRDGHYS---YPY--ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 263

  Fly   549 GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNAD 613
            |||:||..::|:||||||.::.|.:|::|..:||:|.|...||..|..|::.|:.::|.|||::.
Zfish   264 GEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA 328

  Fly   614 T-HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSD---VELKERSSK 674
            | |.||.|:|.:||..||.:|                 |...:::|.|....:   .:||.||.|
Zfish   329 TYHPMSPWVRTLFLQRLPDLL-----------------CMRGNTDRYHYPQMEPQSPDLKPRSKK 376

  Fly   675 SLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKS 739
            .                         |..|        :||..::     ..|.:..|:
Zfish   377 G-------------------------PPGP--------EGDGQAL-----INMLEQATN------ 397

  Fly   740 STEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPH 804
                       .:|:|:..::|:....::..||||.|.|:||:.|..|...::|.||.:...|..
Zfish   398 -----------SVRYISRHIKKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPAVK 451

  Fly   805 IIVSXP 810
            :.:|.|
Zfish   452 MFLSTP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	176/495 (36%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:273305	182/516 (35%)
		Neur_chan_LBD	31..235	CDD:280998	95/209 (45%)
		Neur_chan_memb	242..446	CDD:280999	79/275 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910