Protein Alignment nAChRalpha5 and chrna1

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_571520.1
• Gene: chrna1 / 30725
• ZFINID: ZDB-GENE-980526-137
• Length: 456
• Species: Danio rerio
• Alignment Length: 510
• Identity: 182/510 - (35%)
• Similarity: 280/510 - (54%)
• Gaps: 74/510 - (14%)

  Fly   295 FLLI-----YLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDE 354
            |:||     || ....||  ...|.||:..|...||.:.|||.:..||:.::.||.|:|:|.|||
Zfish     4 FILILPILPYL-YGPAVC--SEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQLISVDE 65

  Fly   355 KNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVV 419
            .||::.:||.||.:|.|::|:||..||||::.:|||...:||||:::||:||..|...::|.|::
Zfish    66 VNQIVTSNVRLKQQWKDVHLQWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLL 130

  Fly   420 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNG 484
            .:.|...:.||.||||.|:|.:..||||.|.|.||.|:||||| .|.:...|....|:|:::.:|
Zfish   131 EHTGMITWTPPAIFKSYCEIVVLHFPFDLQNCSMKLGTWTYDG-NLVIINPDSDRPDLSNFMESG 194

  Fly   485 EWELLGVPGKRNEIYYNCCPE-PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS 548
            ||.:......::.:||.|||: ||:|||:..::.|..||:..|:||||:|.:.:..|.|.||.||
Zfish   195 EWVMKDYRSWKHWVYYACCPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPTDS 259

  Fly   549 GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNAD 613
            |||::|.:::||||||||.::.|.:|:||.||||:|.|....|..|.:|::.|::::|.|||:..
Zfish   260 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPS 324

  Fly   614 THEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLA 678
            ||.|..|:|.:|:..:|.::..|...||                          .:||..|.|..
Zfish   325 THIMPAWVRKIFIDTIPNMMFFSTMKRP--------------------------SQERQEKRLFP 363

  Fly   679 NVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY 743
            ...||.|                                    |....||.:||:|:.|..:.:.
Zfish   364 ADFDISD------------------------------------ISGKPMPASVTYHSPITKNPDV 392

  Fly   744 ELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAV 798
            ...  ::.:::|.|.::.|:|.|:.|.:|||.|||:|.:.|.:|....|:.|:.|
Zfish   393 RSA--IEGVKYIADTMKSDEESNNAAEEWKFVAMVLDHILLCVFMAVCIIGTLGV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	175/487 (36%)
chrna1	NP_571520.1	LIC	21..447	CDD:455710	175/490 (36%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	89/209 (43%)
		Cys-loop	148..162	CDD:349815	7/13 (54%)