DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and Chrne

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_017452660.1	Gene:	Chrne / 29422	RGDID:	2353	Length:	547	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	144/518 - (27%)
Similarity:	248/518 - (47%)	Gaps:	76/518 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |..|.|.|.|.|:...|||....|.:.::..:||..:|.::||.:.|.|:||:.:||.|..|.::
  Rat    77 ELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDYRLNFS 141

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            ..|:.||:.||:|...:|.|::::.|:.|..|...|..||:|...||..::||.|::|||.:::|
  Rat   142 KDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTCAVEVT 206

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLD-LQLQDETGG-------DISSYVLNGEWELLGVPGKRNEIY 499
            :||||.|.|.:.|.|.||:..::: :...|:.|.       |.:::..||||.:...||......
  Rat   207 YFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGMIRHYE 271

  Fly   500 YNCCPEP-YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSL 562
            .....:| ..|:.:.:||||:.|:|..|:|:|||||:.:.||.:.||..: |:|.::.:.:||:.
  Rat   272 GGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQ 336

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            ||||.::|:.:|.||.:|||||.|...:|.:....|::.:::||...|...||..|..:|.:.|.
  Rat   337 TVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLE 401

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQI---LSDVELKERSSKSLLANVLDIDDDFRH 689
            .||.:|.:|.|        |..|.:.:.:.|...:   |...||..:..:|.|     :.:..||
  Rat   402 LLPRLLGLSPP--------PEDPGAASPARRASSVGILLRAEELILKKPRSEL-----VFEGQRH 453

  Fly   690 NCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRF 754
            .                    :|.....::....|...|:.   ..|:.:            :.|
  Rat   454 R--------------------HGTWTAAALCQNLSAAAPEV---RCCVDA------------VNF 483

  Fly   755 ITDQLRKDDECNDIANDWKFAAMVVDRLCL-IIFTMFTILATIAVLLSAPHIIVSXPYGRGGY 816
            :.:..|..:...:..:||......:|.:|. ....:|::.:|:..|              |||
  Rat   484 VAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL--------------GGY 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	141/502 (28%)
Chrne	XP_017452660.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910