Protein Alignment nAChRalpha5 and HTR3E

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 91/363 - (25%)
• Similarity: 155/363 - (42%)
• Gaps: 66/363 - (18%)

  Fly   329 RPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHR 393
            |||.|.|.|.|::....:..|:||               .|::..:.||..:..|:..:.:....
Human    70 RPVTNISVPTQVNISFAMSAILDV---------------VWDNPFISWNPEECEGITKMSMAAKN 119

  Fly   394 IWKPDVLMY-------NSADEGFDGTYQTN------------------VVVRNNGSCLYVPPGIF 433
            :|.||:.:.       ...:....|:::.:                  ..|.|.|...|..|...
Human   120 LWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSNEGRIRYKKPMKV 184

  Fly   434 KSTCKIDITWFPFDDQRCEMKFGSWTY--DGFQLDLQLQDETGGDISSYVL--NGEWELLGVPGK 494
            .|.|.:||.:||||.|.|.:.|.|:.|  |...||::.:.....|.|..:|  :|||||||:...
Human   185 DSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKA 249

  Fly   495 RNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTIL 559
            ..::...  ...|..|.|.:.||||...|..||::|...:.::..|.|.||..||.::...:|:|
Human   250 TAKLSRG--GNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 312

  Fly   560 LSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILN-YHHRNADTHEMSEWIRI 623
            |...|||.|:::.:|  :...||:|.||...:.::..|::.||.|.: .|........:..|:..
Human   313 LGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHS 375

  Fly   624 VFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQ 661
            :       :|..:.|||          |..|:.:::::
Human   376 L-------LLHCNSPGR----------CCPTAPQKENK 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	91/363 (25%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	55/219 (25%)
		Neur_chan_memb	280..>379	CDD:280999	27/107 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910