Protein Alignment nAChRalpha5 and GABRG2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 93/503 - (18%)
• Similarity: 180/503 - (35%)
• Gaps: 128/503 - (25%)

  Fly   269 SSSNSSNSGNSSSTQILNGLNKHSWIFLL--IYLNLSAKVCLAGYHEKR---------------- 315
            ||.|..::|:|..:..:.......||.||  :|...:::.....|.:..
Human     2 SSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDV 66

  Fly   316 --LLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT 378
              :|::||:.|:...||.:... |..:...:.:..|..|:..|.....:::....|.|..|::|:
Human    67 TVILNNLLEGYDNKLRPDIGVK-PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS 130

  Fly   379 SDYGGVKDLRIPPH---RIWKPDVLMYNS--ADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCK 438
            :    :|.||:..:   :||.||....||  ||..:..|....:.:.|:|..||.......:.|:
Human   131 T----IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191

  Fly   439 IDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW----------ELLGVPG 493
            :.:..||.|:..|.::|.||:....|..:     ..|.||::.....|          .:.|:..
Human   192 LQLHNFPMDEHSCPLEFSSWSRSIAQAGM-----CSGVISAHYSLRFWGSTDPPTLASRVAGISD 251

  Fly   494 --KRNEIYY--------------------------------NCCPEPYIDITFAIIIRRRTLYYF 524
              .|.||.|                                ......|:.::....:.||..|:.
Human   252 GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFT 316

  Fly   525 FNLIIPCVLIASMALLGFTLPPDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN 588
            ....|||.||..::.:.|.:..|: ..:.|||:|.:|::|....:..:::|..|....:  ..|.
Human   317 IQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM--DLFV 379

  Fly   589 CIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSD 653
            .:.|:...|.:.....|:|...|                                    ..|..|
Human   380 SVCFIFVFSALVEYGTLHYFVSN------------------------------------RKPSKD 408

  Fly   654 TSSERKHQIL-------SDVELKERSSKSLLANVLDI---DDDFRHNC 691
            ...::|:.:|       ..::::.||:...:.|...:   |:::.:.|
Human   409 KDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYEC 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	82/457 (18%)
GABRG2	NP_944493.2	LIC	69..512	CDD:455710	82/436 (19%)
		LGIC_ECD_GABAAR_G	90..311	CDD:349801	42/229 (18%)
		Cys-loop	190..204	CDD:349801	4/13 (31%)