Protein Alignment nAChRalpha5 and Chrna4

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_038960311.1
• Gene: Chrna4 / 25590
• RGDID: 2346
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 204/611 - (33%)
• Similarity: 296/611 - (48%)
• Gaps: 124/611 - (20%)

  Fly   300 LNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVW 364
            |..|:.:....:.|:|||..|...||...|||.|.||.:.:.|||::.|:||||||||::.||||
  Rat   186 LPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVW 250

  Fly   365 LKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVP 429
            :|.||:|..|||:..||..|..:|||...||:||:::||:||..|..|:.|...:..:|...:.|
  Rat   251 VKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTP 315

  Fly   430 PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGK 494
            |.|:||:|.||:|:||||.|.|.|||||||||..::|| :...:..|...:..:|||.::...|.
  Rat   316 PAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL-VSMHSRVDQLDFWESGEWVIVDAVGT 379

  Fly   495 RNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTIL 559
            .|...|.||.|.|.|||:|.||||..|:|..||||||:||:.:.:|.|.||.:.|||::|.:::|
  Rat   380 YNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVL 444

  Fly   560 LSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIV 624
            |||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.|||:..||.|..|:|.|
  Rat   445 LSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRV 509

  Fly   625 FLCWLPWILRMSRPG------RPLILEFPTTPCSDTSSERKHQ----------------ILSDVE 667
            ||..:|.:|.|.||.      |.||             |..|:                ||||:.
  Rat   510 FLDIVPRLLFMKRPSVVKDNCRRLI-------------ESMHKMANAPRFWPEPVGEPGILSDIC 561

  Fly   668 LKERSSKSLLANVLDIDDDFRHNCR--PM-----------------TPGGTLP------------ 701
            .:..|......|..|...:.:..||  |:                 :||...|
  Rat   562 NQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIK 626

  Fly   702 -------HNPAFYRTV------------YGQGDDGSIG--------------------PIG---- 723
                   |.|:.....            |....||:..                    |:.
  Rat   627 ARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQAS 691

  Fly   724 ----STRMPDAVTHHTCIKSS----------TEYELGLILKEIRFITDQLRKDDECNDIANDWKF 774
                :.:.|..|:..|.:|:.          ....|...::.:::|.|.|:.:|....:..|||:
  Rat   692 PCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKY 756

  Fly   775 AAMVVDRLCLIIFTMFTILATIAVLL 800
            .|||:||:.|.:|.:..:|.|:.:.|
  Rat   757 VAMVIDRIFLWMFIIVCLLGTVGLFL 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	202/598 (34%)
Chrna4	XP_038960311.1	LGIC_ECD	199..405	CDD:355788	99/206 (48%)
		Cys-loop	323..337	CDD:349787	9/13 (69%)
		Neur_chan_memb	412..781	CDD:397193	99/381 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910