Protein Alignment nAChRalpha5 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_434693.1
• Gene: Chrnb4 / 25103
• RGDID: 2351
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 191/505 - (37%)
• Similarity: 285/505 - (56%)
• Gaps: 53/505 - (10%)

  Fly   307 CLAGYHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEW 369
            |.....|::|:.|||:.  ||.|.||..:.|..:.:...|:|.|:|.|:|:.|::.|::|||.||
  Rat    20 CRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEW 84

  Fly   370 NDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFK 434
            .|..|.||:|.|.||..||||..|:|.||:::||:||..::.:..|||:||:|||..::||.|:|
  Rat    85 TDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYK 149

  Fly   435 STCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIY 499
            |.|||::..||||.|.|.:||.|||||..::|:.|:..| ..:..:..:|||:::.:||:|.
  Rat   150 SACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPT-AIMDDFTPSGEWDIVALPGRRT--- 210

  Fly   500 YNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTV 564
            .|.....|:|:|:..||:|:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||:||.
  Rat   211 VNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTF 275

  Fly   565 FLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWL 629
            ||.::::.:|.||..:||:|.|....|.:|..|:|:|:.:||.|||:..||.|:.|::..||..|
  Rat   276 FLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKL 340

  Fly   630 PWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPM 694
            |..|.|.|||..:.|.....|      .:.|...:|.     ::.|.|
  Rat   341 PTFLFMKRPGLEVSLVRVPHP------SQLHLATADT-----AATSAL----------------- 377

  Fly   695 TPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTC-------IKSSTEY--ELGLILK 750
              |.|.|.|      :|| .....:.|:.:. ...||:.||.       ::||..:  :|...|:
  Rat   378 --GPTSPSN------LYG-SSMYFVNPVPAA-PKSAVSSHTAGLPRDARLRSSGRFREDLQEALE 432

  Fly   751 EIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            .:.||...|..||....:..||||.|||||||.|.:|....||.|:.:.|
  Rat   433 GVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	190/499 (38%)
Chrnb4	NP_434693.1	LIC	21..483	CDD:455710	190/504 (38%)
		LGIC_ECD	53..230	CDD:475126	77/180 (43%)