Protein Alignment nAChRalpha5 and Chrna5

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_058774.2
• Gene: Chrna5 / 25102
• RGDID: 2347
• Length: 467
• Species: Rattus norvegicus
• Alignment Length: 509
• Identity: 179/509 - (35%)
• Similarity: 270/509 - (53%)
• Gaps: 93/509 - (18%)

  Fly   309 AGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMN 373
            |..||..|..||.:.|....|||.:.||.:::.|||.:.|::||||||||:.||||||.||.|:.
  Rat    43 AAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVK 107

  Fly   374 LRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCK 438
            ||||..||||:|.:|:|...:|.||::::::||..|:|. .|..|||.||:..:..|..:||:|.
  Rat   108 LRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGA-STKTVVRYNGTVTWTQPANYKSSCT 171

  Fly   439 IDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCC 503
            ||:|:||||.|.|.||||||||||.|:|:.|:|: ..|.:.:..|||||::...|.:.....:||
  Rat   172 IDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ-DVDRTDFFDNGEWEIMSAMGSKGNRTDSCC 235

  Fly   504 PEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNM 568
            ..||  ||::.:|:|..|:|...|||||:.::.:.::.|.||.:.|||:||..::|:||||||.:
  Rat   236 WYPY--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLV 298

  Fly   569 VAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE-MSEWIRIVFLCWLPWI 632
            :.|.:|::|..:||:|.|....|..|..|::.|:..:|.|||::.||. |:.|:|.:||..||.:
  Rat   299 IEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKL 363

  Fly   633 LRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPG 697
            |                 |..:.::|
  Rat   364 L-----------------CMRSHADR--------------------------------------- 372

  Fly   698 GTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKD 762
                     |.|...:.:.|: ||                ||....|..|..  ||:||..:.|:
  Rat   373 ---------YFTQREEAESGA-GP----------------KSRNTLEAALDC--IRYITRHVVKE 409

  Fly   763 DECNDIANDWKFAAMVVDRLCLIIFTMFTILAT----IAVLLSAPHIIVSXPYG 812
            ::..::..||||.|.|:||:.|..|.:.:|:.|    :.|:....:|||....|
  Rat   410 NDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIG 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	173/493 (35%)
Chrna5	NP_058774.2	LIC	41..448	CDD:273305	174/492 (35%)
		Neur_chan_LBD	47..250	CDD:280998	97/206 (47%)
		Neur_chan_memb	257..446	CDD:280999	73/272 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910