DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and Chrna3

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_434692.2	Gene:	Chrna3 / 25101	RGDID:	2345	Length:	499	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	196/514 - (38%)
Similarity:	298/514 - (57%)	Gaps:	39/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 SWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            |.:.|::.|..:|.   |...|.||...|.:.||.:.|||.|.|.|:.:.|.:::.|::.|||.|
  Rat    11 SMLMLVLMLLPAAS---ASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVN 72

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            |::.||:|||..|||..|:|..|||.||:.:|:|..:|||||:::||:||..|....:|..:::.
  Rat    73 QIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKY 137

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEW 486
            .|...::||.||||:||||:|:||||.|.|.||||||:||..::||.|.. :..::..|..:|||
  Rat   138 TGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWESGEW 201

  Fly   487 ELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEK 551
            .::..||.::||.||||.|.|.|||:::.|||..|:|..||||||:||:.:.:|.|.||.|.|||
  Rat   202 AIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEK 266

  Fly   552 LSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE 616
            ::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||.|:|...||.
  Rat   267 VTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHT 331

  Fly   617 MSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKH--QILSDVELKERS-SKSLLA 678
            |..|::.|||..||.::.|:|         ||:...||...|..  ..||::....|: |||
  Rat   332 MPTWVKAVFLNLLPRVMFMTR---------PTSGEGDTPKTRTFYGAELSNLNCFSRADSKS--- 384

  Fly   679 NVLDIDDDFRHNCRPMTP--GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSST 741
                        |:...|  .||..:  ..:|.|.......::....|:...|||..    .|:.
  Rat   385 ------------CKEGYPCQDGTCGY--CHHRRVKISNFSANLTRSSSSESVDAVLS----LSAL 431

  Fly   742 EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ..|:...::.:::|.:.::..:...:|.:|||:.|||:||:.|.:|.:..||.|..:.|
  Rat   432 SPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	191/493 (39%)
Chrna3	NP_434692.2	LIC	24..490	CDD:273305	191/499 (38%)
		Neur_chan_LBD	29..235	CDD:280998	96/206 (47%)
		Neur_chan_memb	242..489	CDD:280999	91/276 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910