Protein Alignment nAChRalpha5 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001382047.1
• Gene: Chrnb1 / 24261
• RGDID: 2349
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 167/556 - (30%)
• Similarity: 264/556 - (47%)
• Gaps: 136/556 - (24%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDV---DEKNQLLVTNVWLKLEWNDMNL 374
            |.:||..|...|::..||.....|.:.:|.||||.|:|.:   :||::.:.|.|:|.|||.|..|
  Rat    27 EGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLVRENEKDEEMSTKVYLDLEWTDYRL 91

  Fly   375 RWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKI 439
            .|:.:::.|::.||:....:|.|||::.|:.|..||.....||||...||..:.|||:::|:|.|
  Rat    92 SWDPAEHDGIESLRVTAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSI 156

  Fly   440 DITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGD--------ISSYVLNGEWELL------- 489
            .:|:||||.|.|.|.|.|::||..::.|:...:..|.        ..:::.||:||::
  Rat   157 QVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIYIHEGTFIENGQWEIIHKPSRLI 221

  Fly   490 --------GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPP 546
                    |..|.|.|            :.|.:||||:.|:|..|:|.||:||..:|:..|.|||
  Rat   222 HLPGDRRGGKEGHREE------------VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPP 274

  Fly   547 DSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRN 611
            |:|||:.|.:..||:|||||.::|:.:|.||.|||::..|....|.:|..||:.::::||.|||:
  Rat   275 DAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTFSVILSVVVLNLHHRS 339

  Fly   612 ADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSL 676
            ..||:|..|:|.:|:..||..|.:.|| :|               ||.       :|.|
  Rat   340 PHTHQMPFWVRQIFIHKLPPYLGLKRP-KP---------------ERD-------QLPE------ 375

  Fly   677 LANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSI---------------------- 719
                                    ||:....|:.:|:|.|...
  Rat   376 ------------------------PHHSFSPRSGWGRGTDEYFIRKPPCDFLFPKLNRFQPESPA 416

  Fly   720 --------GPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAA 776
                    ||..:..:|.              ||..::..|.::..||::.::.:.:..||:|.|
  Rat   417 PDLRRFIDGPPRAVGLPQ--------------ELREVISSISYMARQLQEQEDHDALKEDWQFVA 467

  Fly   777 MVVDRLCLIIFTMFTILATIAVLLSAP-HIIVSXPY 811
            ||||||.|..|.:||.:.|:.:.|.|. |:....|:
  Rat   468 MVVDRLFLWTFIVFTSVGTLVIFLDATYHLPPPEPF 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	164/544 (30%)
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	76/232 (33%)
		Neur_chan_memb	255..490	CDD:397193	84/301 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..384		9/71 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910