Protein Alignment nAChRalpha5 and GABRR3

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 71/367 - (19%)
• Similarity: 140/367 - (38%)
• Gaps: 82/367 - (22%)

  Fly   295 FLLIYLNLSAKVCLAG----YHEK-----------------------------RLLHDLLDPYNT 326
            |..|::.|...||.|.    .|::                             :|||  ::..:.
Human    10 FTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLH--IEDNDF 72

  Fly   327 LERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRW-NTSDYGGVKDLRIP 390
            ..||....| |:.:...:.:..|..:.|.|.......:|:..|.|..|.: :|::.....|.|:
Human    73 AMRPGFGGS-PVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRL- 135

  Fly   391 PHRIWKPDVLMYNSADEGFDGTYQTNVVVR--NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEM 453
            ..:||.||:...:|.......|...|:::|  .:|:.|........:.|.:|.:.||.|.|.|.:
Human   136 TRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSL 200

  Fly   454 KFGSWTYDGFQLDL-------QLQDETGGDISSYVLNGEWELLGV-----PGKRNEIYYNCCPEP 506
            :..|:.|:...|.|       .|..|....:|.:.:.......|:     .|..|.::.|
Human   201 ELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFIN----- 260

  Fly   507 YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGF-----TLPPDSGEKLSLGVTILLSLTVFL 566
                   .::||...::......|.:|:..::.:.|     .:|    .::|||:|.:|:::..:
Human   261 -------FVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVP----ARVSLGITTVLTMSTII 314

  Fly   567 NMVAETMPATSDAVPLLGTYFNCI-MFMVASSVVSTILILNY 607
            ..|:.:||..|        |...: :::..||:...:.::.|
Human   315 TAVSASMPQVS--------YLKAVDVYLWVSSLFVFLSVIEY 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	64/345 (19%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:455710	64/322 (20%)
		LGIC_ECD_GABAAR_rho	82..267	CDD:349806	41/197 (21%)
		Cys-loop	184..198	CDD:349806	6/13 (46%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573	347..448		1/2 (50%)