DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and HTR3D

DIOPT Version :10

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:XP_054201603.1 Gene:HTR3D / 200909 HGNCID:24004 Length:456 Species:Homo sapiens


Alignment Length:343 Identity:79/343 - (23%)
Similarity:133/343 - (38%) Gaps:54/343 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   330 PVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRI 394
            ||.|.|....::...||..|.:.  .:::...|......|::..::||..:.||:|...:....:
Human    55 PVTNYSVATHVNISFTLSAIWNC--YSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENL 117

  Fly   395 WKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTC--KIDITWFPF---DDQRCEMK 454
            |..||.:..|.|:...|...:..:|:...:.:        |.|  .....|.|.   ...|.|.:
Human   118 WLSDVFIEESVDQTPAGLMASMSIVKATSNTI--------SQCGWSASANWTPSISPSMDRAEPR 174

  Fly   455 FGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRR- 518
              :|.  ......|:...|     |:....||.|||:  ::..|........|....|.:.||. 
Human   175 --AWR--RMSRSFQIHHRT-----SFRTRREWVLLGI--QKRTIKVTVATNQYEQAIFHVAIRHR 228

  Fly   519 -RTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDA--- 579
             |...|..|.::|..::.::..|.|.||.:||......:|:||..:|||.|:.:.:||||.:   
Human   229 CRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHA 293

  Fly   580 ----------VPL-LGTYFNCIMFMVASSVVSTILILN-YHHRNADTHEMSEWIRIVFLCWLPWI 632
                      .|| .|.||...:.::..|::.||.|.: .|........:..|:..:       :
Human   294 SLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSL-------L 351

  Fly   633 LRMSRPGRPLILEFPTTP 650
            |..:..||..    ||.|
Human   352 LHCTGQGRCC----PTAP 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:455710 79/343 (23%)
HTR3DXP_054201603.1 LGIC_ECD 30..228 CDD:475126 41/193 (21%)
LGIC_TM_5-HT3 232..455 CDD:349865 37/145 (26%)
TM1 helix 232..256 CDD:349865 5/23 (22%)
TM2 helix 264..285 CDD:349865 7/20 (35%)
TM3 helix 310..332 CDD:349865 6/21 (29%)
TM4 helix 430..452 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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