Protein Alignment nAChRalpha5 and acr-23

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_504024.2
• Gene: acr-23 / 191606
• WormBaseID: WBGene00000062
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 141/561 - (25%)
• Similarity: 254/561 - (45%)
• Gaps: 100/561 - (17%)

  Fly   316 LLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSD 380
            |.:::::.|.....|.:.:..|:.::..|.|.|||.|:|..|.|:.|.|....|.|..|.|:.|:
 Worm    30 LANNIMENYQKGLIPKVRKGSPINVTLSLQLYQIIQVNEPQQYLLLNAWAVERWVDQMLGWDPSE 94

  Fly   381 YGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQ-TNVVV----RNNGS---CLYVPPGIFKSTC 437
            :....::......||.||..:|||.:.....:.: |:|.:    :|.|:   .||  |.|:|.:|
 Worm    95 FDNETEIMARHDDIWLPDTTLYNSLEMDDSASKKLTHVKLTTLGKNQGAMVELLY--PTIYKISC 157

  Fly   438 KIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDI--SSYVLNGEWELLGVPGKRNEIYY 500
            .:::.:||||.|.|.|.||||::|...:|...:..|.|.|  ::::.|..|.:||....|.|..|
 Worm   158 LLNLKYFPFDTQTCRMTFGSWSFDNSLIDYFPRTFTNGPIGLANFLENDAWSVLGTKVNREEKKY 222

  Fly   501 NCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGF--TLPPDSG-------------E 550
            .|||..|..:.:.::|:|:.|||..|||.|..:|..::::||  ::.|.:.             |
 Worm   223 TCCPVNYTLLHYDVVIQRKPLYYVLNLIAPTAVITFISIIGFFTSVNPFTNFCNVSSSVHDLRQE 287

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMV------ASSVVSTILILNYHH 609
            |::||:|.|||:::.:.||::.||:||..|||:..::..::.::      ||||:....:.:..:
 Worm   288 KITLGITTLLSMSIMIFMVSDKMPSTSTCVPLIALFYTLMITIISVGTLAASSVIFVQKLGSIGN 352

  Fly   610 RNAD-----THEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELK 669
            ..|.     ||.::.::    |..:|.:::.:...|              :.|.||:       |
 Worm   353 PPASKTMKWTHRIAPFV----LIQMPLVMKQAYAKR--------------AKEEKHR-------K 392

  Fly   670 ERSSK-SLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTH 733
            ..|.| |:...|..:..| ........|.|.:..|.      .....:..||.:.|.||.::.|.
 Worm   393 RMSRKNSMWTKVYHLARD-HSKLMETVPDGAVKFNQ------ISDFKNNDIGNMESPRMAESQTS 450

  Fly   734 HT-CIKSSTEYELGLILKEIRFITD-----------QLRKDDEC--NDIANDWKFAAMVVDRLCL 784
            .| .....|.:...|.:.|:..:..           :::....|  |.:..:|.:.|.|::|:.|
 Worm   451 ETFAAPMDTSFTESLHIPELNRVASSNSIQSVLKPTEIQLTPYCTRNIVELEWDWVAAVLERVFL 515

  Fly   785 IIFTMFTILATIAVLLSAPHIIVSXPYGRGGYCYWFYYKIN 825
            |.||:..:.:.|.:.|               |.::.:|..|
 Worm   516 IFFTICFLFSAIGINL---------------YGWYIWYTEN 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	138/536 (26%)
acr-23	NP_504024.2	Neur_chan_LBD	27..242	CDD:280998	66/213 (31%)
		Neur_chan_memb	249..529	CDD:280999	67/311 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910