Protein Alignment nAChRalpha5 and acr-19

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001129756.1
• Gene: acr-19 / 191605
• WormBaseID: WBGene00000058
• Length: 560
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 228/574 - (39%)
• Similarity: 329/574 - (57%)
• Gaps: 85/574 - (14%)

  Fly   294 IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQL 358
            :.:||:....:||...|.||:||...|.:.||.|.|||.|||:.:.:..|:...||:|:|||:|:
 Worm    12 VSILIWETKCSKVIWTGDHERRLYAKLAENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQI 76

  Fly   359 LVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNG 423
            :.:||||::.|.|..|.|:.|::|.:|::|:|.:.|||||||:|||.|:.||.|:..|.||...|
 Worm    77 MNSNVWLRMSWTDHYLTWDPSEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTG 141

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWEL 488
            :..::||.|.:|:|.|||.:||||.|.|.||||||||.||..||   ..|....::|..||||||
 Worm   142 NVTWIPPAIIRSSCAIDIAYFPFDTQHCTMKFGSWTYSGFFTDL---INTTISPATYKPNGEWEL 203

  Fly   489 LGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLS 553
            ||:..:|:..:|.||||||.|:||.:.||||||||.|||::||:||:|:|||.||||.|.||||:
 Worm   204 LGLTSQRSIFFYECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLN 268

  Fly   554 LGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE-M 617
            |||||.:||.||:.||||.||.||||:||:..||:||||.|.:|||:|::.||:|||:.:.:: |
 Worm   269 LGVTIFMSLCVFMIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPM 333

  Fly   618 SEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQ----------IL--------- 663
            :::::.:.|.|||.:|.|.||.   :||.........|..:|.|          ||
 Worm   334 NKFLKTLLLGWLPTLLGMERPD---VLELSVHGAHYASDNKKKQRQYLIEVERHILTRPNGNGHS 395

  Fly   664 ----------------SDVELKERSSKSLLANVLD------------IDDDF-RHNC----RPMT 695
                            ||.:....|.|...|:::.            :|... ::.|    ||:.
 Worm   396 AVDKAVHLDLSTGNPHSDAKKSSPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTRPLE 460

  Fly   696 PG-GTLPH------NPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIR 753
            .| .|:.|      ||.....:|...::      ..|:..|...||             ||.|:|
 Worm   461 NGSATINHKSSPQINPINNNNIYKCANN------QKTQFEDRHFHH-------------ILNELR 506

  Fly   754 FITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIV 807
            .|:.::||::..:.:..||.||:.||||:|.:.|:.|..:.|..:..:|||:.|
 Worm   507 VISARVRKEEAMHALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLFV 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	218/548 (40%)
acr-19	NP_001129756.1	LIC	31..548	CDD:273305	217/541 (40%)
		Neur_chan_LBD	31..235	CDD:280998	102/206 (50%)
		Neur_chan_memb	242..>354	CDD:280999	62/111 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050