Protein Alignment nAChRalpha5 and acr-15

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_505206.2
• Gene: acr-15 / 191602
• WormBaseID: WBGene00000054
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 192/524 - (36%)
• Similarity: 287/524 - (54%)
• Gaps: 68/524 - (12%)

  Fly   295 FLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            |||:...|:....     |.||::||:..|...|||.|:.|.|:.:|.|:.|.|||::.||.:.|
 Worm     9 FLLLITQLNGSPA-----EVRLINDLMSGYVREERPTLDSSKPVVVSLGVFLQQIINLSEKEEQL 68

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            ..|.|||.:|.|.||||..:.|..|.|||.||..:|.||:|:|||.|..||.:|:.|:|..:.|:
 Worm    69 EVNAWLKFQWRDENLRWEPTAYENVTDLRHPPDALWTPDILLYNSVDSEFDSSYKVNLVNYHTGN 133

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELL 489
            ..::||||||.:||:||.|||||:|.|..|||||||...::.|:..|   .|.|.::.||||.::
 Worm   134 INWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTYTRDKIQLEKGD---FDFSEFIPNGEWIII 195

  Fly   490 GVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSL 554
            ..........|.||||.|.||||.:.:|||||||.||||.|.:|...:.:||||:.|::.||:.|
 Worm   196 DYRTNITVKQYECCPEQYEDITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSPETCEKVGL 260

  Fly   555 GVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHE-MS 618
            .:::.|::.:||.:::|..|.||:||||||.:|:...|:...:...|:.:.::|.||...|| |.
 Worm   261 QISVSLAICIFLTIMSELTPQTSEAVPLLGVFFHTCNFISVLATSFTVYVQSFHFRNQHVHERMD 325

  Fly   619 EWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDI 683
            .|:|.:.|.|.||:|||..|.|                |...|.|:: ..|.|:.:..:|...
 Worm   326 FWMRFILLEWSPWLLRMKMPDR----------------ENNFQTLTE-SWKGRNRRESMARTA-- 371

  Fly   684 DDDFRHNCRPMTP----GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYE 744
               |.:...|:|.    |..|..|  |...:|         .:...::.|              |
 Worm   372 ---FEYADGPVTQIHSMGIMLKDN--FEELIY---------QVKQEKIAD--------------E 408

  Fly   745 LGL----ILKEIRFITDQLRKDDECND----IANDWKFAAMVVDRLCLIIFTMFTILATIAVLLS 801
            .|:    :|::|......:|:.|:.||    :|.:|:|||:|||||||:.|::..::.:|.:.|.
 Worm   409 KGIERLRVLQKIYDHVKMIREHDDDNDEDSRVALEWRFAAIVVDRLCLLAFSLLIVVVSIIIALR 473

  Fly   802 APHI 805
            ||::
 Worm   474 APYL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	186/501 (37%)
acr-15	NP_505206.2	LIC	19..470	CDD:455710	185/505 (37%)
		LGIC_ECD_nAChR	47..225	CDD:349798	83/180 (46%)
		Cys-loop	146..160	CDD:349798	10/13 (77%)