Protein Alignment nAChRalpha5 and acr-14

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_495716.1
• Gene: acr-14 / 191601
• WormBaseID: WBGene00000053
• Length: 500
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 198/555 - (35%)
• Similarity: 294/555 - (52%)
• Gaps: 100/555 - (18%)

  Fly   293 WIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQ 357
            :|.|..|:.:...|     .|.|||..|.:.|::.||||.|.|.||.:.....|.||:|||||||
 Worm     6 FILLTFYIQVKGSV-----DEYRLLQYLKENYDSFERPVENSSAPLDVKVRFLLNQIMDVDEKNQ 65

  Fly   358 LLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRI-----PPHRIWKPDVLMYNSADEGFDGTYQTNV 417
            ::....::...|||..|.|:...:||::|:|.     ...::|:||||::||..|.||.||.:..
 Worm    66 VMSILAYMDYHWNDYKLTWDPKLFGGIRDVRFSGDDDASFKLWRPDVLLFNSVSESFDSTYSSRF 130

  Fly   418 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDG--FQLDLQLQDETG--G--- 475
            :|.:||.....|||||:..|:||:|::|||.|.|.:|.|||||:|  ..||..|....|  |
 Worm   131 IVSSNGDVQQNPPGIFRFVCQIDVTYYPFDKQTCFLKLGSWTYNGQYINLDFLLTQIIGLHGIPI 195

  Fly   476 --------------------DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRT 520
                                |:..|:.||||:|.|.||||  :......:.|.::.|.|.|||||
 Worm   196 VVEPERSSTNYASYFVNESIDLQVYLQNGEWDLEGTPGKR--VVQKFGTDEYHELYFYIHIRRRT 258

  Fly   521 LYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGT 585
            |.|..|||||.::|:.|.:||||||||:.||::|..|:|||:..||.||:.|.|..|.:||:|..
 Worm   259 LAYGINLIIPSLVISMMTILGFTLPPDACEKITLETTVLLSVIFFLQMVSSTSPPQSQSVPILAA 323

  Fly   586 YFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTP 650
            :|:|.:.:||.|.|.|:|.|:.|||..:|||||..:|.:|:.|||:||.|.:|      :.|.||
 Worm   324 FFSCCLMLVACSCVFTVLTLSLHHRKPETHEMSPTMRKIFIDWLPYILCMCKP------DHPKTP 382

  Fly   651 CSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGD 715
                    |.::|         .||:               .|:....|:|..
 Worm   383 --------KPKVL---------GKSI---------------APIHRLSTIPML------------ 403

  Fly   716 DGSIGPIGSTRMPDA---VTHH--TCIKSSTEY--ELGLILKEIRFITDQLRKDDECNDIANDWK 773
              ::..:..|..||.   |.|.  ..||:::..  ||.:|.::|..:.|::.:|.:.:.:.::|:
 Worm   404 --NLPRVSQTTFPDKNVFVYHEVPAVIKNTSRICAELLIIERDIEKMLDKIEEDTKEDMLRSEWR 466

  Fly   774 FAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVS 808
            ||||.||||||.:|:.|..:.|..:::  |||:.:
 Worm   467 FAAMAVDRLCLYVFSAFITMITCGLIV--PHILAN 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	191/527 (36%)
acr-14	NP_495716.1	LIC	21..483	CDD:273305	189/515 (37%)
		Neur_chan_LBD	21..258	CDD:280998	92/238 (39%)
		Neur_chan_memb	265..491	CDD:280999	94/277 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880