Protein Alignment nAChRalpha5 and acr-11

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 228/530 - (43%)
• Similarity: 319/530 - (60%)
• Gaps: 78/530 - (14%)

  Fly   284 ILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQ 348
            |.|.:|.     :|..:.:.:.:|.....|.:|..|||..||.|||||.|.|.||::...|.|.|
 Worm     2 IFNLINS-----ILSLVIIHSNLCDGSVAETKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQ 61

  Fly   349 IIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP--PHRIWKPDVLMYNSADEGFDG 411
            |:|||||||::..|.||...|.|..|:|....|||::|:|.|  ...|||||||:||||.|.||.
 Worm    62 ILDVDEKNQIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDS 126

  Fly   412 TYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG- 475
            |:::|::..:.|:.:::|||:.|..|::|:||||||||.|||||||||:.|:.:|||:.|:|.|
 Worm   127 TFKSNLLTYHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGT 191

  Fly   476 ---DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASM 537
               |:|:|::||||:::....||...||.||||||..:.:.:.||||||||.||||||.:||:.|
 Worm   192 QSMDLSTYLVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLM 256

  Fly   538 ALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 602
            |:|||..|||:|||::|.|||||::..||:||:|..|.||:||||:|.:|:|.|.:|::|||.||
 Worm   257 AILGFMFPPDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTI 321

  Fly   603 LILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVE 667
            ::||.|.|:||:|||:..:|.|.|.:|||:|.|||||
 Worm   322 VVLNLHFRSADSHEMNPLVRRVLLEFLPWLLFMSRPG---------------------------- 358

  Fly   668 LKERSSKSLLANVLDIDDDFRHNCRPMTP-GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAV 731
                 .|.:.|||:|..|....  :|..| ...||.|.|.|        :..|..:.|.
 Worm   359 -----YKFVKANVIDSTDKMPK--KPKNPLDCNLPSNHAGY--------EAQILLLHSV------ 402

  Fly   732 THHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATI 796
              ||               |:|.:.....|::....|..||:||||||||.||::||:|.:::.:
 Worm   403 --HT---------------ELRRVVAFYNKEEHDERIQTDWRFAAMVVDRACLLLFTVFIVISIL 450

  Fly   797 AVLLSAPHII 806
            |:::||||||
 Worm   451 AIMMSAPHII 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	217/495 (44%)
acr-11	NP_491906.1	LIC	25..456	CDD:273305	217/496 (44%)
		Neur_chan_LBD	26..239	CDD:280998	107/212 (50%)
		Neur_chan_memb	246..447	CDD:280999	102/266 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm4815
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760