Protein Alignment nAChRalpha5 and acr-11

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 228/530 - (43%)
• Similarity: 319/530 - (60%)
• Gaps: 78/530 - (14%)

  Fly   284 ILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQ 348
            |.|.:|.     :|..:.:.:.:|.....|.:|..|||..||.|||||.|.|.||::...|.|.|
 Worm     2 IFNLINS-----ILSLVIIHSNLCDGSVAETKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQ 61

  Fly   349 IIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP--PHRIWKPDVLMYNSADEGFDG 411
            |:|||||||::..|.||...|.|..|:|....|||::|:|.|  ...|||||||:||||.|.||.
 Worm    62 ILDVDEKNQIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDS 126

  Fly   412 TYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG- 475
            |:::|::..:.|:.:::|||:.|..|::|:||||||||.|||||||||:.|:.:|||:.|:|.|
 Worm   127 TFKSNLLTYHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGT 191

  Fly   476 ---DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASM 537
               |:|:|::||||:::....||...||.||||||..:.:.:.||||||||.||||||.:||:.|
 Worm   192 QSMDLSTYLVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLM 256

  Fly   538 ALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTI 602
            |:|||..|||:|||::|.|||||::..||:||:|..|.||:||||:|.:|:|.|.:|::|||.||
 Worm   257 AILGFMFPPDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTI 321

  Fly   603 LILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVE 667
            ::||.|.|:||:|||:..:|.|.|.:|||:|.|||||
 Worm   322 VVLNLHFRSADSHEMNPLVRRVLLEFLPWLLFMSRPG---------------------------- 358

  Fly   668 LKERSSKSLLANVLDIDDDFRHNCRPMTP-GGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAV 731
                 .|.:.|||:|..|....  :|..| ...||.|.|.|        :..|..:.|.
 Worm   359 -----YKFVKANVIDSTDKMPK--KPKNPLDCNLPSNHAGY--------EAQILLLHSV------ 402

  Fly   732 THHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATI 796
              ||               |:|.:.....|::....|..||:||||||||.||::||:|.:::.:
 Worm   403 --HT---------------ELRRVVAFYNKEEHDERIQTDWRFAAMVVDRACLLLFTVFIVISIL 450

  Fly   797 AVLLSAPHII 806
            |:::||||||
 Worm   451 AIMMSAPHII 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	217/495 (44%)
acr-11	NP_491906.1	LIC	25..456	CDD:455710	217/496 (44%)
		LGIC_ECD_nAChR	51..238	CDD:349798	91/186 (49%)
		Cys-loop	152..166	CDD:349798	10/13 (77%)