Protein Alignment nAChRalpha5 and acr-10

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 198/585 - (33%)
• Similarity: 292/585 - (49%)
• Gaps: 114/585 - (19%)

  Fly   294 IFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQL 358
            :|.::.|.:....|...  |.:|..|:|..|..|.|||....:.|::...:.|.||:::|.:||:
 Worm    10 LFFILSLIIIESECSKA--ENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNLDGQNQI 72

  Fly   359 LVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP--PHRIWKPDVLMYNSADEGFDGTYQTNVVVRN 421
            :..|.|||..|.|..|:|:...|..:..:|..  .::||:||:|:||||.|.||.::::|.||.|
 Worm    73 IEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKSNEVVYN 137

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL-----QDETGGDISSYV 481
            .|...::|||||:::||:|||:||||||.|.:|||||||.|..|||.:     ..|...|:|:|.
 Worm   138 TGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSELSIDLSTYT 202

  Fly   482 LNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPP 546
            .:|||.|...|..::..|.:||.|||..:||.:.:|||||:|.||:|:|.:||:.|.|:||.||.
 Worm   203 PSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMTLMGFCLPA 267

  Fly   547 -DSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
             |..||:....|||||:..|:.:|:|..|.||::|||||.:|:.:..:.:.|...||.:||:.:|
 Worm   268 HDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESVPLLGMFFSSLTLISSVSTAFTITVLNFRYR 332

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKS 675
            ......|......|||.|:||:|.|.|||                          |..|:|.:..
 Worm   333 QVQNIHMHPIFYKVFLIWIPWLLLMKRPG--------------------------VFYKKRRATV 371

  Fly   676 LLANVLDIDDDFRHNCRPMTP----------GGTLP------------HN-PAFY----RTVYGQ 713
            .....:...|:...:|.|..|          ..|||            |: ||.:    |.|
 Worm   372 QAREEISFFDNGDDDCCPKPPEFDYSLSIDSADTLPLPPRPKPLLKKMHSVPAEHLHLDRKV--- 433

  Fly   714 GDDGSIGPIGSTRMPDAVT------HHTCIKSSTEYELGLILKEIRFITD--QLRKD-------- 762
            ||    |.:.|.|.|..:|      |....:..|::|     |.|:...|  :|||:
 Worm   434 GD----GILKSQRRPLVLTKNVNKSHSLRSRRFTQFE-----KYIKKCIDDAKLRKNSTYSTYSM 489

  Fly   763 ---------DECNDIAN--------------DWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPH 804
                     ||...:.|              |||||||.:|||||::.|:..::....::||.||
 Worm   490 MIITYYRQIDEMLKLLNRRLDKQRKYLFKQEDWKFAAMALDRLCLLLITLLIVMCLFGMILSTPH 554

  Fly   805  804
             Worm   555  554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	192/562 (34%)
acr-10	NP_508692.3	Neur_chan_LBD	27..241	CDD:280998	90/213 (42%)
		Neur_chan_memb	248..>361	CDD:280999	46/112 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880