Protein Alignment nAChRalpha5 and acr-9

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 234/560 - (41%)
• Similarity: 328/560 - (58%)
• Gaps: 85/560 - (15%)

  Fly   300 LNLSAKVCLAGYH----------EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDE 354
            |.|:|..|:. :|          |.|||.||...|:..||||.|.|:||.:|..:.|.||:||||
 Worm     6 LRLTALHCVL-FHLLTEVHSSADEYRLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDE 69

  Fly   355 KNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP--PHRIWKPDVLMYNSADEGFDGTYQTNV 417
            |||::....|::.:|.|..|:|:.|:|||:||:|||  .:.|||||||:||||||.||.||..|.
 Worm    70 KNQVITLVAWIEYQWTDYKLKWDPSEYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNY 134

  Fly   418 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQ-------DETGG 475
            ||...|..|.|||||.|.:||||||:||||||.|.:|||||||.|..:||::.       .:.|.
 Worm   135 VVSYTGDVLQVPPGILKLSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLRINGPEGKNISDEGI 199

  Fly   476 DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            |:..||.||||.||.||.:.....::  .:||..:.|.:||:||||||..|||||..||:.|.:|
 Worm   200 DVQYYVQNGEWNLLAVPARHETNIFD--EQPYPSLFFYLIIQRRTLYYGLNLIIPSFLISLMTVL 262

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            |||||||:|||::|.:|||||:..||:|||:..|.||:||||:|.:|:|.|.:|::|||.|:|:|
 Worm   263 GFTLPPDAGEKITLEITILLSVCFFLSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLVL 327

  Fly   606 NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            |.|:|..:|||||.::|.:.|.||||:|.|.|||:.:.      .|:...:|:     ::.:.|:
 Worm   328 NLHNRKPETHEMSPFLRELLLIWLPWLLLMRRPGKTIF------NCTHLKAEK-----AEEKAKQ 381

  Fly   671 RSSK------------------SLLANV-------LDIDDDF--RHN-CRPMTPGGTLPHNPAFY 707
            .|.|                  ||:.|:       :|.:.:|  :|| ..|:.|....|
 Worm   382 GSIKNGVGPGKPTDSVHPSEGLSLMKNIKLGRQQTIDFEYEFHVQHNHLMPVAPSEMTP------ 440

  Fly   708 RTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY------ELGLILKEIRFITDQLRKDDECN 766
            |..|            |..|.::......:....:|      ||..|..:.|.:..::.:|:...
 Worm   441 RVTY------------SKVMAESYVEDVVMTELNKYMQKACLELKNISSQTRAMRKKMEEDERDE 493

  Fly   767 DIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII 806
            ..|||||||||||||.|||.|::|.:::|..::.|:||:|
 Worm   494 QAANDWKFAAMVVDRCCLITFSVFIVVSTCGIMFSSPHLI 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	225/531 (42%)
acr-9	NP_510285.2	LIC	28..525	CDD:273305	225/527 (43%)
		Neur_chan_LBD	28..242	CDD:280998	109/215 (51%)
		Neur_chan_memb	249..525	CDD:280999	110/304 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I1903
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H593
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.880