Protein Alignment nAChRalpha5 and acr-9

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 234/560 - (41%)
• Similarity: 328/560 - (58%)
• Gaps: 85/560 - (15%)

  Fly   300 LNLSAKVCLAGYH----------EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDE 354
            |.|:|..|:. :|          |.|||.||...|:..||||.|.|:||.:|..:.|.||:||||
 Worm     6 LRLTALHCVL-FHLLTEVHSSADEYRLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDE 69

  Fly   355 KNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIP--PHRIWKPDVLMYNSADEGFDGTYQTNV 417
            |||::....|::.:|.|..|:|:.|:|||:||:|||  .:.|||||||:||||||.||.||..|.
 Worm    70 KNQVITLVAWIEYQWTDYKLKWDPSEYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNY 134

  Fly   418 VVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQ-------DETGG 475
            ||...|..|.|||||.|.:||||||:||||||.|.:|||||||.|..:||::.       .:.|.
 Worm   135 VVSYTGDVLQVPPGILKLSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLRINGPEGKNISDEGI 199

  Fly   476 DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            |:..||.||||.||.||.:.....::  .:||..:.|.:||:||||||..|||||..||:.|.:|
 Worm   200 DVQYYVQNGEWNLLAVPARHETNIFD--EQPYPSLFFYLIIQRRTLYYGLNLIIPSFLISLMTVL 262

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            |||||||:|||::|.:|||||:..||:|||:..|.||:||||:|.:|:|.|.:|::|||.|:|:|
 Worm   263 GFTLPPDAGEKITLEITILLSVCFFLSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLVL 327

  Fly   606 NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            |.|:|..:|||||.::|.:.|.||||:|.|.|||:.:.      .|:...:|:     ::.:.|:
 Worm   328 NLHNRKPETHEMSPFLRELLLIWLPWLLLMRRPGKTIF------NCTHLKAEK-----AEEKAKQ 381

  Fly   671 RSSK------------------SLLANV-------LDIDDDF--RHN-CRPMTPGGTLPHNPAFY 707
            .|.|                  ||:.|:       :|.:.:|  :|| ..|:.|....|
 Worm   382 GSIKNGVGPGKPTDSVHPSEGLSLMKNIKLGRQQTIDFEYEFHVQHNHLMPVAPSEMTP------ 440

  Fly   708 RTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY------ELGLILKEIRFITDQLRKDDECN 766
            |..|            |..|.::......:....:|      ||..|..:.|.:..::.:|:...
 Worm   441 RVTY------------SKVMAESYVEDVVMTELNKYMQKACLELKNISSQTRAMRKKMEEDERDE 493

  Fly   767 DIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHII 806
            ..|||||||||||||.|||.|::|.:::|..::.|:||:|
 Worm   494 QAANDWKFAAMVVDRCCLITFSVFIVVSTCGIMFSSPHLI 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	225/531 (42%)
acr-9	NP_510285.2	LIC	28..525	CDD:455710	225/527 (43%)
		Neur_chan_LBD	28..242	CDD:460752	109/215 (51%)