DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and acr-5

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001367477.1	Gene:	acr-5 / 191596	WormBaseID:	WBGene00000044	Length:	598	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	160/578 - (27%)
Similarity:	260/578 - (44%)	Gaps:	94/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 FAAQLRSSSSSSSNSSNSGNSSSTQ--------ILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKR 315
            |..||:   .|..|::.:.|::..|        .|..||:..:|                ..::|
Worm    61 FQTQLK---KSLENTTAAYNATFMQELIEERQRYLEKLNEGQFI----------------NDQRR 106

  Fly   316 LLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT 378
            |:.:||||  |.....|..:.:.|.:::..::|.||:||||..|.:..|||:...|.|..|.||.
Worm   107 LVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFLDWNP 171

  Fly   379 SDYGGVKDLRIPPHRIWKPDVLMYNSAD------EGF------DGTYQTNVVVRNNGSCLYVPPG 431
            .|||.:....:|.|:||.||..:|||.:      |..      .|.:...   ::......:.|.
Worm   172 VDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQK---KDGAKVQLMFPA 233

  Fly   432 IFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRN 496
            |:|.:|::|:.|||:|.|.|.....|||:|...:|......| .::.:...|.|||::.....|.
Worm   234 IYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLSST-VNLGNMARNDEWEVISFEFVRV 297

  Fly   497 EIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG----EKLSLGVT 557
            |..:.||..|::.:...::|||:.|||..||::|..:|..:|:.||..|..|.    |||.||:.
Worm   298 EETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSERDEKLYLGIN 362

  Fly   558 ILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL---ILNYHHRNADTHEMSE 619
            .||:::|.:.||...||:||..|||:..|:..|:.::   ||.|.|   :|..|.:......:|:
Worm   363 TLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVI---VVGTFLATGVLAIHGQKHYNKPISD 424

  Fly   620 WIRIVFLCWLPWILRMSRPGRPLILEF----PTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
              ||..|.:.|            ::||    |.|...|..:|  ..::|:    :|.|..|...:
Worm   425 --RIRKLIYNP------------VVEFFILSPPTSLIDLWTE--FGVISE----QRHSTHLDPLL 469

  Fly   681 LDIDDDFRHNCR--PMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKS--ST 741
            |...|...|..|  |....|::.......::.|..  ...:..|  ||.   .|.|..:|:  ..
Worm   470 LQHMDPISHTTRADPQHFFGSISSQMCDLQSTYSY--TARLATI--TRQ---YTQHAKMKALRKN 527

  Fly   742 EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
            :|.:.:...:.|.:..| :....|   :.:|:|.|.|:||:.|.||..||....|.::
Worm   528 QYRMSMDTSQARGVKKQ-KMQRRC---SLEWEFLANVLDRILLTIFCGFTFAVFIILI 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	149/516 (29%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	149/514 (29%)
acr-5	NP_001367477.1	Neur_chan_LBD	104..321	CDD:397192	68/220 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910