Protein Alignment nAChRalpha5 and acr-5

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 578
• Identity: 160/578 - (27%)
• Similarity: 260/578 - (44%)
• Gaps: 94/578 - (16%)

  Fly   259 FAAQLRSSSSSSSNSSNSGNSSSTQ--------ILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKR 315
            |..||:   .|..|::.:.|::..|        .|..||:..:|                ..::|
 Worm    61 FQTQLK---KSLENTTAAYNATFMQELIEERQRYLEKLNEGQFI----------------NDQRR 106

  Fly   316 LLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT 378
            |:.:||||  |.....|..:.:.|.:::..::|.||:||||..|.:..|||:...|.|..|.||.
 Worm   107 LVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFLDWNP 171

  Fly   379 SDYGGVKDLRIPPHRIWKPDVLMYNSAD------EGF------DGTYQTNVVVRNNGSCLYVPPG 431
            .|||.:....:|.|:||.||..:|||.:      |..      .|.:...   ::......:.|.
 Worm   172 VDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQK---KDGAKVQLMFPA 233

  Fly   432 IFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRN 496
            |:|.:|::|:.|||:|.|.|.....|||:|...:|......| .::.:...|.|||::.....|.
 Worm   234 IYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLSST-VNLGNMARNDEWEVISFEFVRV 297

  Fly   497 EIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG----EKLSLGVT 557
            |..:.||..|::.:...::|||:.|||..||::|..:|..:|:.||..|..|.    |||.||:.
 Worm   298 EETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSERDEKLYLGIN 362

  Fly   558 ILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL---ILNYHHRNADTHEMSE 619
            .||:::|.:.||...||:||..|||:..|:..|:.::   ||.|.|   :|..|.:......:|:
 Worm   363 TLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVI---VVGTFLATGVLAIHGQKHYNKPISD 424

  Fly   620 WIRIVFLCWLPWILRMSRPGRPLILEF----PTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
              ||..|.:.|            ::||    |.|...|..:|  ..::|:    :|.|..|...:
 Worm   425 --RIRKLIYNP------------VVEFFILSPPTSLIDLWTE--FGVISE----QRHSTHLDPLL 469

  Fly   681 LDIDDDFRHNCR--PMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKS--ST 741
            |...|...|..|  |....|::.......::.|..  ...:..|  ||.   .|.|..:|:  ..
 Worm   470 LQHMDPISHTTRADPQHFFGSISSQMCDLQSTYSY--TARLATI--TRQ---YTQHAKMKALRKN 527

  Fly   742 EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
            :|.:.:...:.|.:..| :....|   :.:|:|.|.|:||:.|.||..||....|.::
 Worm   528 QYRMSMDTSQARGVKKQ-KMQRRC---SLEWEFLANVLDRILLTIFCGFTFAVFIILI 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	149/516 (29%)
acr-5	NP_001367477.1	LIC	104..581	CDD:455710	149/514 (29%)
		Neur_chan_LBD	104..321	CDD:460752	68/220 (31%)