DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha5 and lgc-19

DIOPT Version :10

Sequence 1:NP_001356885.1 Gene:nAChRalpha5 / 34826 FlyBaseID:FBgn0028875 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_502905.2 Gene:lgc-19 / 190895 WormBaseID:WBGene00013655 Length:400 Species:Caenorhabditis elegans


Alignment Length:387 Identity:89/387 - (22%)
Similarity:166/387 - (42%) Gaps:80/387 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 DLLDPYNTLERPVLNESDP----------LQLSFG--------------LTLMQIIDVDEKNQLL 359
            |.||....|.:.:..:.||          :.|..|              |..:::::|.|..:.:
 Worm    29 DFLDVQRNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKI 93

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSAD-EGFDGTYQTNVVVRNNG 423
            ...:.:...|.|..|.||.|.:.....:.:...::|.|.:.::...| ..|.......:.:.|.|
 Worm    94 SVVMEIMEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRLICIENTG 158

  Fly   424 SCL-YVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL------QLQDETGGDISSYV 481
            ... ||...: .:.|::|::.||||.|.|:::|....:...|:|:      ::.||.   |...:
 Worm   159 FIWDYVSVRV-SANCEMDVSRFPFDTQICQIRFCLPIFYRVQVDILNEIYEEIMDER---IFKTM 219

  Fly   482 LNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLP 545
            .|.||:||.:..:...:.||..........|.|.|||..|||.:.::.|..:|..::::| |...
 Worm   220 GNSEWKLLNLTNRVEALVYNDNMGTMDLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFLNG 284

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCIMFMVASSVVSTILILNYH 608
            .|...:|::|:|.::::|..|.::|:.:|.|.: :||||.|  .|.::.::|.::|:.|.     
 Worm   285 ADKMSRLNVGLTNIMTMTFILGVMADKIPRTGN-IPLLGIYIIINLVIMLIAIAIVTAIT----- 343

  Fly   609 HRNADTHEMSEW-----------IRIVFLCWLPWILRMSRPGRPL------ILEFPTTPCSD 653
                   |:.:|           :|.....:|         ||||      |||..|  |::
 Worm   344 -------ELRKWASPKLRKKKTALRAQLESFL---------GRPLEYTSAIILELMT--CAN 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha5NP_001356885.1 LIC 313..802 CDD:455710 89/387 (23%)
lgc-19NP_502905.2 LGIC_ECD_cation 75..257 CDD:349790 42/185 (23%)
Cys-loop 172..186 CDD:349790 7/13 (54%)
LGIC_TM_cation 259..>346 CDD:349853 26/99 (26%)
TM1 helix 259..284 CDD:349853 7/24 (29%)
TM2 helix 292..313 CDD:349853 5/20 (25%)
TM3 helix 323..346 CDD:349853 6/34 (18%)

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