Protein Alignment nAChRalpha5 and lgc-7

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_502777.2
• Gene: lgc-7 / 190370
• WormBaseID: WBGene00013300
• Length: 439
• Species: Caenorhabditis elegans
• Alignment Length: 393
• Identity: 112/393 - (28%)
• Similarity: 189/393 - (48%)
• Gaps: 35/393 - (8%)

  Fly   320 LLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGV 384
            |::.|::..|||.||.|.|.::..:..|.::.:|...:.:..:....|:|.|..|.||.||| .:
 Worm    35 LMEGYDSSIRPVNNERDILIINISMNTMSVLTLDPAEETINFSSEFILQWKDEFLFWNKSDY-NI 98

  Fly   385 KDLRIPPHRIWKPDVLMYNSADEGF--DGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFD 447
            ..|::....:|.||..:..|.|..:  |.: :..|.|:::|:.......:|.:.|.:::..||:|
 Worm    99 TWLKLKESFLWTPDTTVSTSIDTNYLIDAS-ERYVSVKHDGTVRQSIYAVFTNLCDMNVDKFPYD 162

  Fly   448 DQRCEMKFGSWTYDGFQL------DLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEP 506
            .|.|.:|.|.|:|...::      |:...|...||...   |.||:..|:.....|     ..:|
 Worm   163 QQTCMIKMGPWSYTTQEVTCIVGRDIAPNDTDFGDFHG---NSEWDFEGIVSSVGE-----TEDP 219

  Fly   507 YIDIT-----FAIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLPPDSG---EKLSLGVTILLSL 562
            .::.|     ||:.::||..:|.:.|:||..:|..:.:.| ||...:.|   |:::||:|.|||.
 Worm   220 DVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFTPTANHGLREERVNLGITTLLSS 284

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            .|.|.:||..||.||: :||||.:....:|:||..|:..:|:|..|.| |.|.|...      ..
 Worm   285 AVILQIVANAMPKTSE-LPLLGNFILAEIFVVAIGVLFAVLVLTLHQR-AHTREWRP------PA 341

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCR 692
            |:.|||||:...:.|...........:::||.|.......|.:...:||.:....|.::.|...|
 Worm   342 WMLWILRMTGSSKFLSRNITKIRHKSSTAERIHYTGEGAYLFKNLDESLQSVREYIQEEDRDYFR 406

  Fly   693 PMT 695
            .:|
 Worm   407 ELT 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	112/393 (28%)
lgc-7	NP_502777.2	LIC	6..437	CDD:273305	112/393 (28%)
		Neur_chan_LBD	28..238	CDD:280998	55/212 (26%)
		Neur_chan_memb	245..>349	CDD:280999	42/111 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010