Protein Alignment nAChRalpha5 and pbo-5

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 594
• Identity: 135/594 - (22%)
• Similarity: 241/594 - (40%)
• Gaps: 142/594 - (23%)

  Fly   250 IAFISYLGSFAAQLRSSSSSSSNS-SNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHE 313
            ::.:.:|.:|....:.:::|::.| .:|...:...:||.||..|....|..:|.:....:.| ..
 Worm     4 LSILQHLLTFLILSKINATSTTESYFDSSEEAPNVLLNHLNNESEGEELTQINDTQPAFVPG-SS 67

  Fly   314 KRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT 378
            |||...||..:|....|    ...|.:.:.|.|:.|:.:||..|.:...:::...|.|.:|.|:.
 Worm    68 KRLTEYLLSRHNLNAPP----DGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDP 128

  Fly   379 SDYGGVKDLRIPPHRIWKPDVLMYNS------ADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTC 437
            :.:||:....||..:||.||::::|.      |.|......:....:..||:.:...|.:...:|
 Worm   129 ALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSC 193

  Fly   438 KIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNC 502
            :|:|..||.|||||.::..||.|.  |..::|...|...:..|..|.||.||.:         |.
 Worm   194 EINIRHFPLDDQRCAIEIASWAYG--QEKIRLHAHTDHSLEHYKRNEEWHLLNL---------NV 247

  Fly   503 CPEPY-------IDITFAIIIRRRTLYYFFNLIIPCVLIASMALLG----FTLPPDSGEKLSLGV 556
            ..|.|       .::.|.|.::||.|:|...|..|..::.:::::|    |:...:..|:.:|||
 Worm   248 SEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGV 312

  Fly   557 TILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSE-W 620
            |.:|::.|...:|:|.:|.:|..||||..||...|.:|:.:.::|.:::..|.......|.|: |
 Worm   313 TAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGRYGDEPSDFW 377

  Fly   621 IRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDD 685
            :|    |:|                  ..|...||:.||:::
 Worm   378 MR----CFL------------------LKPVFRTSNRRKYRM----------------------- 397

  Fly   686 DFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILK 750
                             ||.              .|.....:.:|.......|.|||.. |.::|
 Worm   398 -----------------NPE--------------EPTQVILVSEAKNGEVLTKKSTELN-GTVVK 430

  Fly   751 EIRF------ITDQLRK-DDECNDIANDWKFAAM-------------------VVDRLCLIIFTM 789
            ||..      :.:.:|| .:.|..|  .|:...:                   :.:||.::.  |
 Worm   431 EIMLSSRLEALEEYIRKMVNRCETI--KWELDEIDAAENIELVRRRSTNGYVRISERLDILF--M 491

  Fly   790 FTILATIAV 798
            |..|:|:.:
 Worm   492 FLFLSTVTI 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	122/530 (23%)
pbo-5	NP_001024240.1	Neur_chan_LBD	68..272	CDD:280998	60/218 (28%)
		Neur_chan_memb	306..>364	CDD:280999	20/57 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010