Protein Alignment nAChRalpha5 and lgc-1

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 88/365 - (24%)
• Similarity: 164/365 - (44%)
• Gaps: 56/365 - (15%)

  Fly   305 KVCLAGYH-----EKRLLHDLLDPYN-------TLER-----------PVLNESDPLQLSFG-LT 345
            |..:|.|:     :|||..||...|:       ||.:           |.:.|   |:|:.. |.
 Worm     3 KAEMATYNKFLADQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITE---LKLTMAMLK 64

  Fly   346 LMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGF- 409
            |:.:::|:||...|...:   .||.|..|:||..:|||:..:.:|...||.|:|.:.::.:..|
 Worm    65 LVDVVEVEEKVTFLFDYL---AEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTIADAHEVKFF 126

  Fly   410 --DGTYQTNVVVRNNGSCLYVPPGIFKST-----CKIDITWFPFDDQRCEMKFGSWTYDGFQLDL 467
              |...:| ..:..||:     .|.:.||     |::|:..||.|...|.:.....||...:..:
 Worm   127 ESDDAPRT-AWINYNGT-----TGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVI 185

  Fly   468 QLQDETGGDISSYVLNGEWEL--LGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIP 530
            :...|......|.:.||||::  :||..:.....::....      |...|.|...:|...:::|
 Worm   186 KSDMEPLPKPLSQLGNGEWKVTYIGVAEEIGNGNFSAVQR------FVARIERNPGFYVTLVMVP 244

  Fly   531 CVLIASMALLGFTLPPDS-GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCIMF 592
            ...|..::::...|..:: |||:::|:|.::::|..|.::|:.:|.|. .:|||..|  ...::.
 Worm   245 AFFINFLSIIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTK-RIPLLAIYVIVGLVIV 308

  Fly   593 MVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWI 632
            |.:..||.|:.::..|.:.....:..:.:...|..|..|:
 Worm   309 MASIGVVLTLPLIRNHLKKRQKGKEEKPVETRFSKWFGWL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	85/352 (24%)
lgc-1	NP_504154.5	LIC	84..>335	CDD:455710	64/263 (24%)