Protein Alignment nAChRalpha5 and lgc-18

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510029.3
• Gene: lgc-18 / 187977
• WormBaseID: WBGene00011360
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 329
• Identity: 83/329 - (25%)
• Similarity: 155/329 - (47%)
• Gaps: 55/329 - (16%)

  Fly   312 HEKRLLHDLLDPYNTLERPVLNESDPLQ----------------LSFGLTLMQIIDVDEKNQLLV 360
            ::.:|:.|:...|:....||..:.||.|                ..:.|.|:::|:.:||
 Worm    33 NQVKLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYYLKLVEVIEPEEK----- 92

  Fly   361 TNVWLKLE--WNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMY--NSADEGFDGTYQTNVVVRN 421
            .:|.|::.  |.|..:.|::|.||.:|.|.:...::|.|.:.::  |...:..|..::. |.|.|
 Worm    93 VSVVLEMAEYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRM-VCVEN 156

  Fly   422 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFG------------SWTYDGFQLDLQLQDETG 474
            .|.............|.:|::.||:|.|.|.::|.            |..|:|. |:..:.::.|
 Worm   157 TGHTYTTLSVKISLNCPLDVSMFPYDSQTCRIQFNMPLFFMQQVEMFSQIYEGI-LNSTVWEKMG 220

  Fly   475 GDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDI---TFAIIIRRRTLYYFFNLIIPCVLIAS 536
                    |.||||..:......:.|.   :...|:   ||.|.|||..:||.:.:|.|..:|.:
 Worm   221 --------NSEWELANLTHSVELLSYG---DGLGDMQLATFEIRIRRNPMYYIYMIIFPSFIINA 274

  Fly   537 MALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVS 600
            ::::| |....|...||::|:|.::::|..|.::|:.:|.|. ::||||.|....:|::..:|..
 Worm   275 LSIIGVFLKKTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLGIYIIVNLFIMIVAVGL 338

  Fly   601 TILI 604
            ||::
 Worm   339 TIVL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	83/328 (25%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	48/199 (24%)
		LGIC_TM_cation	259..>341	CDD:349853	25/82 (30%)
		TM1 helix	263..284	CDD:349853	5/20 (25%)
		TM2 helix	292..313	CDD:349853	5/20 (25%)
		TM3 helix	323..341	CDD:349853	4/17 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010