Protein Alignment nAChRalpha5 and lgc-17

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510028.2
• Gene: lgc-17 / 187976
• WormBaseID: WBGene00011359
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 413
• Identity: 97/413 - (23%)
• Similarity: 173/413 - (41%)
• Gaps: 110/413 - (26%)

  Fly   293 WIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNES-------------DPLQLSFGL 344
            ||   .|||          |:..|..||...|:.....|.:.|             |....:..|
 Worm    29 WI---DYLN----------HQDNLTRDLFANYDPTISSVYSSSFDYEPSHNHTRTVDRWNYTILL 80

  Fly   345 TLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMY------N 403
            ..:::::|.|..:.:...:.|..:|.|..|.||:|.|..:..:.:...::|.|.:..:      :
 Worm    81 YYLKLVEVQEPEEKVSVVLELVEQWYDPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAFGVNEIID 145

  Fly   404 SADEGFD-------GTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRC---------- 451
            ..|:.|.       |..|..:.||            ..|.|.:|::.||||.|.|
 Worm   146 FRDQDFRIVSIDDIGYIQDYLSVR------------VSSNCPMDVSRFPFDSQTCQICFCLPIFN 198

  Fly   452 --EMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPY--IDI-T 511
              ::|..:..|:|.     ||::    |...:.|.||:::.:..:..::.|:   :.|  :|: .
 Worm   199 IRQVKILNEIYEGI-----LQEK----IIKTMGNSEWKVVSLTNRVEQLKYD---DDYGNMDLAV 251

  Fly   512 FAIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPA 575
            |.|.|||..|||.:.::.|..:|..::::| |....|...||::|:|.::::|..|.::|:.:|.
 Worm   252 FEITIRRNPLYYIYMIVFPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPR 316

  Fly   576 TSDAVPLLGTY--FNCIMFMVASSVVSTILIL------------NYHHRNADTHEMSEWIRIVFL 626
            |. ::||||.|  .|.::.::|.:||..|..|            :|..|..:|...|.   |.:.
 Worm   317 TG-SIPLLGIYIIINLLIMIIAITVVVLITELRQWAVPRLKLKKSYISRKLETFLGSP---IEYT 377

  Fly   627 CWLPWILRMSRPGRPLILEFPTT 649
            |             .::|||.||
 Worm   378 C-------------AILLEFLTT 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	91/393 (23%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	44/205 (21%)
		LGIC_TM	261..>317	CDD:365787	16/55 (29%)
		TM1 helix	261..286	CDD:349850	7/24 (29%)
		TM2 helix	294..315	CDD:349850	5/20 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010