Protein Alignment nAChRalpha5 and lgc-16

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 443
• Identity: 104/443 - (23%)
• Similarity: 187/443 - (42%)
• Gaps: 105/443 - (23%)

  Fly   255 YLGSFAAQLRSSSSSSSNSSNSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHD 319
            ||| |...|.|.|..|:...:.          ||....||   .||||          ::.|.:|
 Worm     2 YLG-FIVTLFSFSDISAFYHDP----------GLYAPGWI---DYLNL----------QENLTND 42

  Fly   320 LLDPYNTLERPV---LNESDPL----------QLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWND 371
            |...|:.....|   :.:.:||          ..:..|..:::::|.|..:.:...:.|...|.|
 Worm    43 LFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLELVERWYD 107

  Fly   372 MNLRWNTSDYGGVKDLRIPPHRIWKP--------DVLMYNSAD-----EGFDGTYQTNVVVRNNG 423
            ..|.||.|.|..|..:.....::|.|        :::.:...|     ..|.|.....:.||
 Worm   108 PRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDYLSVR--- 169

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVL----NG 484
                     ..:.|.:|::.||||.|.|:::|....::..|:.: |.:...|.:...::    |.
 Worm   170 ---------VSANCPMDVSRFPFDSQTCQIRFCLPIFNIRQVKI-LNEIYEGILQEKIIKTMGNS 224

  Fly   485 EWELLGVPGKRNEIYYNCCPEPY--IDI-TFAIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLP 545
            ||:::.:..:..::.|:   :.|  :|: .|.|.|||..|||.:.::.|..:|..::::| |...
 Worm   225 EWKVVSLTNRVEQLKYD---DDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVINGISIVGIFLKS 286

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTY--FNCIMFMVASSVVSTILIL--- 605
            .|...||::|:|.::::|..|.::|:.:|.|. ::||||.|  .|.::.::|.:||..|..|
 Worm   287 ADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLLIMIIAITVVVLITELRQW 350

  Fly   606 ---------NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTT 649
                     :|..|..:|...|.   |.:.|             .::|||.||
 Worm   351 AVPRLKLKKSYMSRKLETFLGSP---IEYTC-------------AILLEFLTT 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	88/385 (23%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	41/197 (21%)
		LGIC_TM	261..>317	CDD:365787	16/55 (29%)
		TM1 helix	261..284	CDD:349850	6/22 (27%)
		TM2 helix	291..315	CDD:349850	7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010