Protein Alignment nAChRalpha5 and lgc-15

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510025.2
• Gene: lgc-15 / 187973
• WormBaseID: WBGene00011356
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 353
• Identity: 87/353 - (24%)
• Similarity: 152/353 - (43%)
• Gaps: 74/353 - (20%)

  Fly   298 IYLNLSAKVCLAGYH-----EKRLLHDLLDPYNTLERPVLNESDPLQ----------------LS 341
            ||.|.|..|  ..|:     :..|..:|...|:....||..:.||.|                |.
 Worm    17 IYYNHSLYV--PKYYDFLETQTNLTKNLFSGYDATISPVYTKVDPTQPLGHDPDAPGRWNYTLLL 79

  Fly   342 FGLTLMQIIDVDEKNQLLVTNVWLKLE-WNDMNLRWNTSDYGGVKDLRIPPHRIWKP-------- 397
            |.|.|:::.:..||    |:.|...:| |.|..|.||..||..:..:......:|.|
 Worm    80 FSLKLVEVTEPQEK----VSVVMEVMEYWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVS 140

  Fly   398 --------DVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMK 454
                    |..:......|...||.:.:|..|               |.:|:..||||.|.|:::
 Worm   141 ELVDLRDTDFRLVGITSYGMVNTYVSVLVSAN---------------CPMDVYKFPFDYQTCQIR 190

  Fly   455 FGSWTYDGFQLDLQLQDETGGDISSYVL----NGEWELLGVPGKRNEIYYNCCPEPYIDI---TF 512
            |....:..::::: ..:...|.::|...    |.||.|:.:..:...:.|:   :.:.::   ||
 Worm   191 FCIPVFTSYEVEI-FNEIYAGVLTSNAWKTMGNSEWNLVNLTHRVETLKYD---DGFANLDLGTF 251

  Fly   513 AIIIRRRTLYYFFNLIIPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPAT 576
            .|.|||..|||.:.:|.|..:|..::::| |....|...||::|:|.::::|..|.::|:.:|.|
 Worm   252 EIKIRRNPLYYIYMIIFPSFIINVVSIIGVFLKGADKMSKLNVGLTNIMTMTFILGVMADKIPRT 316

  Fly   577 SDAVPLLGTYF--NCIMFMVASSVVSTI 602
            . .:||||.|.  |.::.::|..:|:.|
 Worm   317 G-TIPLLGVYIITNLVIMLIAIGIVTVI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	81/333 (24%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	45/206 (22%)
		LGIC_TM_cation	260..>343	CDD:349853	26/83 (31%)
		TM1 helix	264..285	CDD:349853	5/20 (25%)
		TM2 helix	293..314	CDD:349853	5/20 (25%)
		TM3 helix	324..343	CDD:349853	4/18 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010