Protein Alignment nAChRalpha5 and lgc-14

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510024.2
• Gene: lgc-14 / 187972
• WormBaseID: WBGene00011355
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 88/365 - (24%)
• Similarity: 169/365 - (46%)
• Gaps: 59/365 - (16%)

  Fly   295 FLLIYLNLSA-----KVCLAGYH-----EKRLLHDLLDPYNTLERPVLNESDPLQ---------- 339
            |.:|::...|     ::.:..||     :..|..||.:.|:....||.::.||||
 Worm     6 FTVIFIGSHALYYNPELYVPKYHDFIESQTNLTRDLFNGYDPTVSPVYSKIDPLQPLGYDPDAPK 70

  Fly   340 ---LSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLM 401
               .|..|..:::::|:|..:.:...:.:...|.|:.|.||.|.|..:.........:|.|.:..
 Worm    71 RYNYSIMLYSLKLVEVNEPAEKVAVVMEIMEYWYDIRLSWNASLYDDIDTFYTRQSNVWSPTLSA 135

  Fly   402 YNSADEGF---DGTYQTNVVVRNNGSCLYVPPGI---FKSTCKIDITWFPFDDQRCEMKFGSWTY 460
            : .|||..   |..::. |.|.:||   |:...|   ..|:|.:::..||||.|.|::||....:
 Worm   136 F-GADELVDLRDPDFRM-VCVNSNG---YIYDYISVRVSSSCPMNVYKFPFDYQTCQIKFCLPIF 195

  Fly   461 DGFQLDLQLQDETG---GDISSYVLNGEWELLGVPGKRNEIYYNCCPEPY--IDI-TFAIIIRRR 519
            :..::.:..:...|   .|:...:.|.||:|..:..:...:.||   :.:  :|: .|.|.|:|.
 Worm   196 NSVEIQIFNEIYVGVLMSDLWETMGNSEWKLTNLSNRVETLQYN---DGFGNLDLGIFEITIKRN 257

  Fly   520 TLYYFFNLIIPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLL 583
            .|||.:.:|.|..:|..::::| |....|...:|::|:|.::::|..|.::|:.:|.|. .:|:|
 Worm   258 PLYYIYMIIFPSFIINVVSIIGVFLKGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-TIPML 321

  Fly   584 GTYF--NCIMFMVASSVVSTILILNYHHRNADTHEMSEWI 621
            |.|.  |..:.::|..:|:.|.            |:..|:
 Worm   322 GVYIIVNLAIMIIAIGIVTMIT------------ELRHWL 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	83/337 (25%)
lgc-14	NP_510024.2	LGIC_ECD_cation	75..257	CDD:349790	45/189 (24%)
		LGIC_TM	259..349	CDD:365787	26/102 (25%)
		TM1 helix	259..284	CDD:349850	8/24 (33%)
		TM2 helix	292..313	CDD:349850	5/20 (25%)
		TM3 helix	323..345	CDD:349850	5/33 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010