Protein Alignment nAChRalpha5 and lgc-13

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_510023.2
• Gene: lgc-13 / 187971
• WormBaseID: WBGene00011354
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 356
• Identity: 91/356 - (25%)
• Similarity: 170/356 - (47%)
• Gaps: 66/356 - (18%)

  Fly   295 FLLIYLNLSAKVCLAGYHEKRL----LHDLLDPYNTL---------------------ERPVLNE 334
            |:|:.|.||..   |.|::.:|    ..|.|:....|                     .:|:..:
 Worm     5 FILLKLILSTD---AFYYDPQLYVPKYRDYLEAQGNLTADLFKNYEKDVSPVYAWFDTSKPLGYD 66

  Fly   335 SD-PLQLSFGLTL--MQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWK 396
            .| |.:.::.|.|  :::|.|:|..:.:...:.|...|.|..|.||.|||..|..:.....:||.
 Worm    67 PDAPQRYNYTLFLYNLKLIQVNEPEEQVSVVLELMEYWYDPRLSWNASDYKNVTAIFTRQEKIWS 131

  Fly   397 PDVLMY------NSADEGFDGTYQTNVVVRNNGSCLYVPPGI-FKSTCKIDITWFPFDDQRCEMK 454
            |.:..:      :..|:.|      .:|..:|...:|....: ..:.|::|:|.||||.|.|:::
 Worm   132 PTLTPFGVNEIIDFRDQDF------RLVCIDNLGMIYDYLSVRVSANCRMDVTKFPFDSQTCQIR 190

  Fly   455 FG--SWTYDGFQLDLQLQDETGGDISSYVL-----NGEWELLGVPGKRNEIYYNCCPEPYIDITF 512
            |.  .::|    |::::..|....|::|.:     |.||||:.:..:.:.:.||    ...|:..
 Worm   191 FSLPIFSY----LEVKIYTELYEGINNYSMFEVMGNSEWELINLTNRVDFLTYN----DRFDVEL 247

  Fly   513 AII---IRRRTLYYFFNLIIPCVLIASMALLG-FTLPPDSGEKLSLGVTILLSLTVFLNMVAETM 573
            |:.   |.|..||||:.::.|..:|.|::::| |....|...:|::|:|.::::|..|.::::.:
 Worm   248 AVYEIKIARNPLYYFYMIVFPSFVINSVSIVGVFIKGADKMSRLNVGLTNIMTMTFILGVMSDKI 312

  Fly   574 PATSDAVPLLGTYF--NCIMFMVASSVVSTI 602
            |.|.: |||||.|.  |.::.:||..:|:.|
 Worm   313 PRTGN-VPLLGIYIIVNLLIMLVAIIIVTII 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	84/338 (25%)
lgc-13	NP_510023.2	LGIC_ECD_cation	74..257	CDD:349790	48/196 (24%)
		LGIC_TM	259..>335	CDD:365787	24/76 (32%)
		TM1 helix	259..284	CDD:349850	9/24 (38%)
		TM2 helix	292..313	CDD:349850	4/20 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010