Protein Alignment nAChRalpha5 and lgc-12

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_498656.3
• Gene: lgc-12 / 187855
• WormBaseID: WBGene00020048
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 412
• Identity: 112/412 - (27%)
• Similarity: 195/412 - (47%)
• Gaps: 44/412 - (10%)

  Fly   284 ILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQ 348
            |||.||.   |......|.:.::.....:|:.|:..|:..|....|||.|.|..|.::....:..
 Worm     3 ILNNLNN---IQEENTSNFTIEIEYPEINERELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYN 64

  Fly   349 IIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTY 413
            :::|:|:|:.:...:|....|.|..|.|:..::.|::.:.||...:|.||..::|:.:| .|...
 Worm    65 LVEVNEQNEQIKLLIWFPQSWKDDYLVWDPDEWDGIEKITIPKSMVWLPDGYIFNTVEE-TDTLD 128

  Fly   414 QTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDIS 478
            ..||.|..||........:....|.:.:..||||.|.|.::||||||....|...:.:   ..::
 Worm   129 NHNVRVHYNGKVEVDFNKLIDLICPMSVLSFPFDVQLCALQFGSWTYQSHALSFNVLE---ASVN 190

  Fly   479 SYVLNGEWELLGVPG-KRNEIYYNCC--PEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            ....|.||:::.... |:...|.|..  ...|.:|.:.:.:||:.|||...::||..||.:::.:
 Worm   191 ENNKNSEWDIVAFNATKKVSKYMNLIGGDNVYEEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNI 255

  Fly   541 GFTLP----PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVST 601
            |...|    .|..|.:|||:|.:|::.|.|:||...||.:|:.:||||.|......:...:|:.:
 Worm   256 GLFTPHGVHGDREEHVSLGLTTMLTMAVILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVS 320

  Fly   602 ILILNYHHRNADTHEMSEWIRIVFLCWLP--WILRMSRPGR---PLI-LEFPTTPCS--DTSSE- 657
            :||:..|.            |::::..:|  ||.|:....:   ||. :|:.....|  |.:.|
 Worm   321 VLIIFAHE------------RMLYMDAMPPFWIFRLFSKHKNQIPLAEMEYDDLRSSPVDLAQEL 373

  Fly   658 -------RKHQILSDVELKERS 672
                   |||  |.|::.|:::
 Worm   374 RFCIEKVRKH--LEDLDSKDKN 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	105/383 (27%)
lgc-12	NP_498656.3	LIC	29..>327	CDD:455710	87/301 (29%)