Protein Alignment nAChRalpha5 and acr-20

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 591
• Identity: 150/591 - (25%)
• Similarity: 274/591 - (46%)
• Gaps: 89/591 - (15%)

  Fly   275 NSGNSSSTQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQ 339
            :||..::..:|     ||    |:.|.:|:       .:..:.:.:||.||....|.:.:..|::
 Worm     2 SSGRQAAVLLL-----HS----LVLLTVSS-------DQYEIANKILDKYNAGLIPSMGKKSPIE 50

  Fly   340 LSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNS 404
            :.|.:.|.|||.|:|..|.|:.|.|:...|.|..|.|:...:|.|.::.:|.|.||.||..:|||
 Worm    51 VHFSMELYQIISVNEPQQFLMLNAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNS 115

  Fly   405 ---ADEGFDGTYQTNVVVRNNGSCLYVP---PGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGF 463
               .|:.........|.....|:..::.   |.|:|.:|.:::.:||||.|.|.:.|||||:|..
 Worm   116 LVMKDDENRRLLHAKVTTLGEGNGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNT 180

  Fly   464 QLDLQLQDETGG-DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNL 527
            ::|....:|:.. ..::.:.|..|.:|.....|:|..|:|||..|..:.|.:.|:|:.|||..||
 Worm   181 KIDYFAFNESQAIGTTNCIENEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINL 245

  Fly   528 IIPCVLIASMALLGF----TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN 588
            |||..:|..::::||    ::.....||::||:|.|||:::.:.||::.||:||..:||:|.::.
 Worm   246 IIPTSIITFISIIGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYT 310

  Fly   589 CIMFMVA-SSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCS 652
            .::.::: |::.|:::|......|........::.|...     :.|..|...|||::......:
 Worm   311 SMILLISFSTICSSVVIYVQKQGNLGNPPSKNFMNIARA-----VNRFIRMEMPLIMKQAYAQKA 370

  Fly   653 DTSSERKHQ-------------------ILSDVELKERSSK--SLLANVLDIDDDFRH------- 689
            .....|:.|                   :..||:..:.|||  .:|.....||:..:.
 Worm   371 REEKLRRQQMGRKQSLWTRVYKLAREQALRKDVQTSQNSSKFNEVLTPEKLIDNGGKRCTINKDV 435

  Fly   690 NCRPMTPGGTLPHNPAFYRTVYGQGDDGSIG--PIGSTRMPDAVTHHTCI-KSST--EYELGLIL 749
            .|  ::..|.:...   ..|:..:.||..:.  .:.:|..| |:...|.: |:||  .:: .::.
 Worm   436 TC--ISDSGIVAMG---VPTLASEDDDQDVSLLELETTPTP-AMQRPTRLHKASTCGSFD-SMMF 493

  Fly   750 KEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVSXPYGRG 814
            ::|. :....|......:|..||  .|.:::|:.||.|....:|.:|.:.|.
 Worm   494 RQIE-VPVSPRTARNLAEIEYDW--LAALLERIFLITFLFIFVLTSIGINLI------------- 542

  Fly   815 GYCYWF 820
            |:.||:
 Worm   543 GFFYWW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	139/533 (26%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	66/213 (31%)
		LGIC_TM_cation	239..>329	CDD:349853	31/89 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910